Highly Enantioselective Synthesis of N‐Unprotected Unnatural α‐Amino Acid Derivatives by Ruthenium‐Catalyzed Direct Asymmetric Reductive Amination

• Published in: Angewandte Chemie International Edition Vol. 61; no. 25; pp. e202202552 - n/a
• Main Authors: Hu, Le'an, Wang, Yuan‐Zheng, Xu, Lei, Yin, Qin, Zhang, Xumu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 20.06.2022; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Amides; Amination; Amino Acids; Ammonium; Ammonium salts; Asymmetry; Chemistry; Chemistry, Multidisciplinary; Enantiomers; Intermediates; N-Unprotected Amino Acids; Peptides; Physical Sciences; Reductive Amination; Ruthenium; Salts; Science & Technology; Substrates; α-Keto Amides; BRONSTED ACID; BIOMIMETIC TRANSAMINATION; HYDROGEN; COOPERATIVE CATALYSIS; AMMONIA; ESTERS; PROGRESS; ALKYL-ARYL KETONES; N-Unprotected Amino Acids; Ruthenium; α-Keto Amides; Amino Acids; Reductive Amination

An unprecedented highly enantioselective Ru‐catalyzed direct asymmetric reductive amination of α‐keto amides with ammonium salts has been disclosed, efficiently offering valuable enantioenriched N‐unprotected unnatural α‐amino acid derivatives bearing a broad range of aryl or alkyl α‐substituents. T...