Glucose‐Responsive Composite Microneedle Patch for Hypoglycemia‐Triggered Delivery of Native Glucagon

• Published in: Advanced materials (Weinheim) Vol. 31; no. 30; pp. e1901051 - n/a
• Main Authors: GhavamiNejad, Amin, Li, Jason, Lu, Brian, Zhou, Liwei, Lam, Loretta, Giacca, Adria, Wu, Xiao Yu
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.07.2019
• Subjects: composite microneedle patches; Crosslinking; Diabetes; Diabetes mellitus; glucagon delivery; Glucose; glucose‐responsive microgels; Hyaluronic acid; Hyperglycemia; Hypoglycemia; hypoglycemia prevention; Insulin; Materials science; Microgels; Therapy; hypoglycemia prevention; glucagon delivery; glucose-responsive microgels; diabetes; composite microneedle patches

Insulin‐dependent patients with diabetes mellitus require multiple daily injections of exogenous insulin to combat hyperglycemia. However, administration of excess insulin can lead to hypoglycemia, a life‐threatening condition characterized by abnormally low blood glucose levels (BGLs). To prevent h...