Catalytic Asymmetric Synthesis of Axially Chiral Diaryl Ethers through Enantioselective Desymmetrization

• Published in: Angewandte Chemie International Edition Vol. 62; no. 14; pp. e202300481 - n/a
• Main Authors: Bao, Hanyang, Chen, Yunrong, Yang, Xiaoyu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 27.03.2023; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Asymmetric synthesis; Asymmetry; Axial Chirality; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Chiral Phosphoric Acid; Diaryl ethers; Electrophilic Aromatic Amination; Enantiomers; Enantioselective Desymmetrization; Ethers; Organocatalysis; Phosphoric acid; Physical Sciences; Science & Technology; Substrates; BRONSTED ACID; ATROPISOMERS; Electrophilic Aromatic Amination; LIGANDS; Axial Chirality; ATROPOSELECTIVE SYNTHESIS; CONSTRUCTION; Chiral Phosphoric Acid; Organocatalysis; Enantioselective Desymmetrization

Axially chiral diaryl ethers are a type of unique atropisomers bearing two potential axes, which have potential applications in a variety of research fields. However, the catalytic enantioselective synthesis of these diaryl ether atropisomers is largely underexplored when compared to the catalytic a...