COVID‐19 vaccine (mRNA BNT162b2) and COVID‐19 infection‐induced thrombotic thrombocytopenic purpura in adolescents
The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID‐19 vaccination or infection in pediatric or adolescent patient...
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| Published in | Pediatric blood & cancer Vol. 69; no. 6; pp. e29681 - n/a |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Wiley Subscription Services, Inc
01.06.2022
John Wiley and Sons Inc |
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| Abstract | The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID‐19 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID‐19 vaccine or after COVID‐19 infection. Our observations demonstrate that the Pfizer‐BioNTech mRNA vaccine and COVID‐19 infection can act as triggers for the development/relapse of both congenital and acquired TTP. |
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| AbstractList | The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID‐19 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID‐19 vaccine or after COVID‐19 infection. Our observations demonstrate that the Pfizer‐BioNTech mRNA vaccine and COVID‐19 infection can act as triggers for the development/relapse of both congenital and acquired TTP. Abstract The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic purpura (TTP). There is not yet literature that discusses TTP induced by COVID‐19 vaccination or infection in pediatric or adolescent patients. We describe three adolescents presenting with TTP (both de novo and relapsed disease) following administration of the Pfizer COVID‐19 vaccine or after COVID‐19 infection. Our observations demonstrate that the Pfizer‐BioNTech mRNA vaccine and COVID‐19 infection can act as triggers for the development/relapse of both congenital and acquired TTP. |
| Author | Muscal, Eyal Cohen, Clay T. Vorster, Luna Sartain, Sarah E. Kirk, Susan E. Despotovic, Jenny M. |
| AuthorAffiliation | 1 Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA 3 Department of Pediatrics, Section of Rheumatology, Baylor College of Medicine Texas Children's Hospital Houston TX USA 4 Department of Pediatrics, Section of Neurology/Developmental Neuroscience, Baylor College of Medicine Texas Children's Hospital Houston TX USA 2 Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine Texas Children's Hospital Houston TX USA |
| AuthorAffiliation_xml | – name: 1 Department of Pediatrics, Baylor College of Medicine Texas Children's Hospital Houston Texas USA – name: 4 Department of Pediatrics, Section of Neurology/Developmental Neuroscience, Baylor College of Medicine Texas Children's Hospital Houston TX USA – name: 3 Department of Pediatrics, Section of Rheumatology, Baylor College of Medicine Texas Children's Hospital Houston TX USA – name: 2 Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine Texas Children's Hospital Houston TX USA |
| Author_xml | – sequence: 1 givenname: Luna surname: Vorster fullname: Vorster, Luna organization: Texas Children's Hospital – sequence: 2 givenname: Susan E. surname: Kirk fullname: Kirk, Susan E. organization: Texas Children's Hospital – sequence: 3 givenname: Eyal surname: Muscal fullname: Muscal, Eyal organization: Texas Children's Hospital – sequence: 4 givenname: Jenny M. orcidid: 0000-0001-9569-3636 surname: Despotovic fullname: Despotovic, Jenny M. organization: Texas Children's Hospital – sequence: 5 givenname: Clay T. orcidid: 0000-0001-6819-4049 surname: Cohen fullname: Cohen, Clay T. organization: Texas Children's Hospital – sequence: 6 givenname: Sarah E. orcidid: 0000-0003-2204-4568 surname: Sartain fullname: Sartain, Sarah E. email: sartain@bcm.edu organization: Texas Children's Hospital |
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| Cites_doi | 10.1097/BOR.0000000000000776 10.1016/j.clim.2020.108480 10.1111/jth.15418 10.1002/ajh.23527 10.1016/j.transci.2021.103145 10.1016/j.jocn.2020.04.062 10.1172/JCI26007 10.1097/MPH.0b013e3182755c38 10.1016/j.autrev.2020.102524 10.1002/ajh.22091 10.3324/haematol.13524 10.3324/haematol.2008.002493 10.1002/ajh.26132 10.1007/s12185-021-03190-y 10.1182/blood.2021011548 10.1016/j.jaut.2021.102663 10.1111/bjh.17645 10.2169/internalmedicine.49.2957 10.1016/j.clim.2021.108665 10.1016/j.ajem.2021.05.054 |
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| References | 2021; 13 2021; 49 2010; 49 2021; 33 2013; 88 2013; 35 2009; 94 2021; 137 2021; 114 2021; 224 2021; 138 2005; 115 2021; 19 2011; 86 2021; 195 2020; 217 2021; 121 2020; 76 2021; 60 2021; 96 2020; 19 35484992 - Pediatr Blood Cancer. 2022 Dec;69(12):e29749 e_1_2_6_21_1 e_1_2_6_20_1 e_1_2_6_9_1 e_1_2_6_8_1 e_1_2_6_19_1 e_1_2_6_5_1 Shankar K (e_1_2_6_12_1) 2021; 13 e_1_2_6_4_1 e_1_2_6_7_1 e_1_2_6_6_1 e_1_2_6_13_1 Paulsen FO (e_1_2_6_10_1) 2021; 138 e_1_2_6_14_1 e_1_2_6_24_1 e_1_2_6_3_1 e_1_2_6_11_1 e_1_2_6_23_1 e_1_2_6_2_1 e_1_2_6_22_1 e_1_2_6_17_1 e_1_2_6_18_1 e_1_2_6_15_1 e_1_2_6_16_1 |
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| Snippet | The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic... The mRNA COVID-19 vaccine and COVID-19 infection caused by the SARS-CoV-2 virus may be immunologic triggers for the development of thrombotic thrombocytopenic... Abstract The mRNA COVID‐19 vaccine and COVID‐19 infection caused by the SARS‐CoV‐2 virus may be immunologic triggers for the development of thrombotic... |
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| SubjectTerms | acquired TTP Adolescent Adolescents BNT162 Vaccine Child COVID-19 COVID-19 - complications COVID-19 vaccines COVID-19 Vaccines - adverse effects Hematology Hematology: Brief Report Hematology: Brief Reports Humans Infections mRNA mRNA Vaccines Oncology Pediatrics Purpura Purpura, Thrombotic Thrombocytopenic - genetics RNA, Messenger - genetics SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Teenagers Thrombocytopenic purpura Thrombotic thrombocytopenic purpura TTP Vaccination Vaccines Vaccines, Synthetic |
| Title | COVID‐19 vaccine (mRNA BNT162b2) and COVID‐19 infection‐induced thrombotic thrombocytopenic purpura in adolescents |
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