Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials

A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for...

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Bibliographic Details
Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 13; no. 43
Main Authors Tsou, Yung‐Hao, Zhang, Xue‐Qing, Zhu, He, Syed, Sahla, Xu, Xiaoyang
Format Journal Article
LanguageEnglish
Published Germany Wiley Subscription Services, Inc 01.11.2017
Subjects
Alzheimer's disease
Blood-brain barrier
Brain diseases
Circulatory system
drug delivery
Drug delivery systems
Functional groups
Multiple sclerosis
Nanomaterials
Nanotechnology
blood brain barrier
nanotechnology
drug delivery
Online AccessGet full text
ISSN1613-6810
1613-6829
1613-6829
DOI10.1002/smll.201701921

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Abstract A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer‐based, lipid‐based, and inorganic‐based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases. There are numerous variables that can affect the relationship between nanocarriers and the blood brain barrier (BBB). Understanding the composition of nanocarriers and their affinities, and interactions with proteins and receptors on the BBB can allow drug‐loaded carriers to cross the BBB successfully. The size, charge, shape, and method of delivery can be manipulated to increase and enhance brain permeability and bioavailability of loaded therapeutics.
AbstractList A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer‐based, lipid‐based, and inorganic‐based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases.
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood-brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer-based, lipid-based, and inorganic-based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases.A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood-brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer-based, lipid-based, and inorganic-based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases.
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB prevents the passage of certain molecules and pathogens from the circulatory system into the brain. Therefore, it is nearly impossible for therapeutic drugs to target the diseased cells without the assistance of carriers. Nanotechnology is an area of growing public interest; nanocarriers, such as polymer‐based, lipid‐based, and inorganic‐based nanoparticles can be engineered in different sizes, shapes, and surface charges, and they can be modified with functional groups to enhance their penetration and targeting capabilities. Hence, understanding the interaction between nanomaterials and the BBB is crucial. In this Review, the components and properties of the BBB are revisited and the types of nanocarriers that are most commonly used for brain drug delivery are discussed. The properties of the nanocarriers and the factors that affect drug delivery across the BBB are elaborated upon in this review. Additionally, the most recent developments of nanoformulations and nonconventional drug delivery strategies are highlighted. Finally, challenges and considerations for the development of brain targeting nanomedicines are discussed. The overall objective is to broaden the understanding of the design and to develop nanomedicines for the treatment of brain diseases. There are numerous variables that can affect the relationship between nanocarriers and the blood brain barrier (BBB). Understanding the composition of nanocarriers and their affinities, and interactions with proteins and receptors on the BBB can allow drug‐loaded carriers to cross the BBB successfully. The size, charge, shape, and method of delivery can be manipulated to increase and enhance brain permeability and bioavailability of loaded therapeutics.
Author Syed, Sahla
Zhang, Xue‐Qing
Xu, Xiaoyang
Tsou, Yung‐Hao
Zhu, He
Author_xml – sequence: 1
  givenname: Yung‐Hao
  surname: Tsou
  fullname: Tsou, Yung‐Hao
  organization: New Jersey Institute of Technology
– sequence: 2
  givenname: Xue‐Qing
  surname: Zhang
  fullname: Zhang, Xue‐Qing
  email: xueqingjhs@gmail.com
  organization: 800 Dongchuan Road
– sequence: 3
  givenname: He
  surname: Zhu
  fullname: Zhu, He
  organization: New Jersey Institute of Technology
– sequence: 4
  givenname: Sahla
  surname: Syed
  fullname: Syed, Sahla
  organization: New Jersey Institute of Technology
– sequence: 5
  givenname: Xiaoyang
  orcidid: 0000-0002-1634-3329
  surname: Xu
  fullname: Xu, Xiaoyang
  email: xiaoyang.xu@njit.edu
  organization: New Jersey Institute of Technology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29045030$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright 2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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drug delivery
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Snippet A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood–brain barrier (BBB). The BBB...
A major obstacle facing brain diseases such as Alzheimer's disease, multiple sclerosis, brain tumors, and strokes is the blood-brain barrier (BBB). The BBB...
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SubjectTerms Alzheimer's disease
Blood-brain barrier
Brain diseases
Circulatory system
drug delivery
Drug delivery systems
Functional groups
Multiple sclerosis
Nanomaterials
Nanotechnology
Title Drug Delivery to the Brain across the Blood–Brain Barrier Using Nanomaterials
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fsmll.201701921
https://www.ncbi.nlm.nih.gov/pubmed/29045030
https://www.proquest.com/docview/1963516110
https://www.proquest.com/docview/1952529267
Volume 13
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