Multiphoton tomography in differentiation of morphological and molecular subtypes of breast cancer: A quantitative analysis

• Published in: Journal of biophotonics Vol. 14; no. 5; pp. e202000471 - n/a
• Main Authors: Gubarkova, Ekaterina V., Elagin, Vadim V., Dudenkova, Varvara V., Kuznetsov, Sergey S., Karabut, Maria M., Potapov, Arseny L., Vorontsov, Dmitry A., Vorontsov, Alexey Y., Sirotkina, Marina A., Zagaynova, Elena V., Gladkova, Natalia D.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.05.2021; Wiley Subscription Services, Inc
• Subjects: Biomarkers; Biopsy; Breast cancer; Collagen; collagen fibers; Elastin; Extracellular matrix; Fibers; Fluorescence; Invasiveness; Medical imaging; Morphology; multiphoton tomography (MPT); Quantitative analysis; quantitative assessment; Second harmonic generation; second harmonic generation (SHG); Tomography; Tumor cells; Tumors; two‐photon excited fluorescence (TPEF); multiphoton tomography (MPT); collagen fibers; breast cancer; quantitative assessment; second harmonic generation (SHG); two-photon excited fluorescence (TPEF)

In this study multiphoton tomography, based on second harmonic generation (SHG), and two‐photon‐excited fluorescence (TPEF) was used to visualize both the extracellular matrix and tumor cells in different morphological and molecular subtypes of human breast cancer. It was shown, that quantified asse...