Titanium Incorporation into Zr‐Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug‐Resistant Pathogens

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 16; no. 7; pp. e1906240 - n/a
• Main Authors: Chen, Mian, Long, Zhou, Dong, Ruihua, Wang, Le, Zhang, Jiangjiang, Li, Sixiang, Zhao, Xiaohui, Hou, Xiandeng, Shao, Huawu, Jiang, Xingyu
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.02.2020
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacteria; Bacteria - drug effects; Bimetals; Biocompatibility; Cation exchanging; Drug Resistance, Multiple, Bacterial - drug effects; Glycolic acid; MDR bacteria; Metal-organic frameworks; Metal-Organic Frameworks - pharmacology; Nanofibers; Nanoparticles; Nanotechnology; Photochemotherapy - methods; Photodynamic therapy; Reagents; Titanium; Titanium - chemistry; Titanium - pharmacology; titanium incorporation; Toxicity; Wound healing; Wound Healing - drug effects; Zirconium; wound healing; photodynamic therapy; MDR bacteria; titanium incorporation; metal-organic frameworks

This study uses metal–organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug‐resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN‐224) are incorporated with titanium through a...