Construction of Axially Chiral Arylpyrroles via Atroposelective Diyne Cyclization

• Published in: Angewandte Chemie International Edition Vol. 62; no. 23; pp. e202303670 - n/a
• Main Authors: Chen, Yang‐Bo, Liu, Li‐Gao, Chen, Can‐Ming, Liu, Yi‐Xi, Zhou, Bo, Lu, Xin, Xu, Zhou, Ye, Long‐Wu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 05.06.2023; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkynes; Asymmetric Catalysis; Asymmetric synthesis; Axial Chirality; Catalysts; Cations; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Cyclizations; Enantiomers; Heterocycles; Natural products; Oxidation; Physical Sciences; Science & Technology; Substitutes; BRONSTED ACID; BINOL; Heterocycles; DESIGN; Cyclizations; ENANTIOSELECTIVE SYNTHESIS; RESOLUTION; 2+2+2 CYCLOADDITION; INDOLES; ATROPISOMERS; YNAMIDES; Asymmetric Catalysis; Axial Chirality; ACCESS; Alkynes

Axially chiral biaryls widely exist in natural products and pharmaceuticals and are used as chiral ligands and catalysts in asymmetric synthesis. Compared to the well‐established axially chiral 6‐membered biaryl skeletons, examples of 5‐membered biaryls have been quite scarce, and mono‐substituted 3...