Tumor‐Selective Nano‐Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll‐Like Receptors

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 21; no. 1; pp. e2406870 - n/a
• Main Authors: Liu, Yang, Li, Hui, Hao, Yan‐Yun, Huang, Ling‐Ling, Li, Xia, Zou, Jing, Zhang, Shi‐Ying, Yang, Xiao‐Yue, Chen, Hong‐Fei, Guo, Yi‐Xuan, Guan, Yun‐Yan, Zhang, Zhi‐Yue
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.01.2025
• Subjects: Accumulation; Acidosis; Animals; Anticancer properties; Cell Line, Tumor; Efflux; Humans; Immune system; immune therapy; Immunotherapy - methods; lactate metabolism; Lactic Acid - chemistry; Lymphocytes; Metabolism; Mice; monocarboxylate transporters 4 (MCT4); Monocarboxylic Acid Transporters - antagonists & inhibitors; Monocarboxylic Acid Transporters - metabolism; Nanoparticles - chemistry; nano‐dispatcher; Neoplasms - immunology; Neoplasms - metabolism; Neoplasms - pathology; Neoplasms - therapy; Proteins; Receptors; TLR7/8; Toll-Like Receptors - metabolism; Tumor Microenvironment - drug effects; lactate metabolism; immune therapy; nano‐dispatcher; TLR7/8; monocarboxylate transporters 4 (MCT4)

The development of tumors relies on lactate metabolic reprogramming to facilitate their unchecked growth and evade immune surveillance. This poses a significant challenge to the efficacy of antitumor immunity. To address this, a tumor‐selective nano‐dispatcher, PIMDQ/Syro‐RNP, to enforce the immunot...