Chemodivergent Tandem Radical Cyclization of Alkene‐Substituted Quinazolinones: Rapid Access to Mono‐ and Di‐Alkylated Ring‐Fused Quinazolinones

• Published in: Chemistry : a European journal Vol. 29; no. 46; pp. e202301390 - n/a
• Main Authors: Wu, Hong‐Li, Zhang, Wei‐Kang, Zhang, Can‐Can, Wang, Ling‐Tao, Yang, Wen‐Hui, Tian, Wen‐Chan, Ge, Guo‐Ping, Xie, Long‐Yong, Yi, Rongnan, Wei, Wen‐Ting
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 15.08.2023; Wiley Subscription Services, Inc
• Subjects: Alkenes; Alkylation; Aromatic compounds; Chemistry; Chemistry, Multidisciplinary; chemodivergent tandem radical cyclization; Cyclic compounds; Esters; green synthesis; metal- and base-free; Nitriles; Oxidants; Oxidizing agents; Physical Sciences; Quinazolinone; Quinazolinones; remote para-C−H alkylation; Science & Technology; Substitutes; Synthesis; FUNCTIONALIZATION; ANNULATIONS; remote para-C-H alkylation; HETEROCYCLES; metal- and base-free; CASCADE CYCLIZATION; chemodivergent tandem radical cyclization; green synthesis; 1,N-ENYNES; remote para-C−H alkylation

Chemodivergent tandem radical cyclization offers exciting possibilities for the synthesis of structurally diverse cyclic compounds. Herein, we revealed a chemodivergent tandem cyclization of alkene‐substituted quinazolinones under metal‐ and base‐free conditions, this transformation is initiated by...