Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

• Published in: Advanced materials (Weinheim) Vol. 33; no. 36; pp. e2101410 - n/a
• Main Authors: Xu, Cheng, Jiang, Yuyan, Huang, Jingsheng, Huang, Jiaguo, Pu, Kanyi
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2021
• Subjects: Ablation; Adenosine; Animals; Apoptosis - radiation effects; Cancer; cancer therapy; Caspase 3 - metabolism; Cell death; Cell Line, Tumor; Humans; Hyperthermia, Induced; Immunology; Immunomodulators; Immunotherapy; Infrared Rays; Lymphocytes; Materials science; Mice; Nanostructures - chemistry; Near infrared radiation; Neoplasms - radiotherapy; photoactivation; Photothermal Therapy; polymer nanoparticles; Polymers - chemistry; Remote control; second near‐infrared photothermal therapy; Semiconductors; Signal Transduction; T-Lymphocytes, Cytotoxic - drug effects; Theranostic Nanomedicine; Tumors; cancer therapy; polymer nanoparticles; photoactivation; second near-infrared photothermal therapy

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small‐molecule immunomodulators lead to the off‐target adverse effects and insufficient the...