Sulodexide for the Prevention of Recurrent Venous Thromboembolism The Sulodexide in Secondary Prevention of Recurrent Deep Vein Thrombosis (SURVET) Study: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

• Published in: Circulation (New York, N.Y.) Vol. 132; no. 20; pp. 1891 - 1897
• Main Authors: Andreozzi, Giuseppe M., Bignamini, Angelo A., Davì, Giovanni, Palareti, Gualtiero, Matuška, Jiří, Holý, Martin, Pawlaczyk-Gabriel, Katarzyna, Džupina, Andrej, Sokurenko, German Y., Didenko, Yury P., Andrei, Laurentia D., Lessiani, Gianfranco, Visonà, Adriana
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 17.11.2015
• Subjects: Adult; Aged; Anticoagulants - administration & dosage; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Glycosaminoglycans - administration & dosage; Humans; Male; Middle Aged; Original; Recurrence; Secondary Prevention - methods; Venous Thromboembolism - diagnosis; Venous Thromboembolism - prevention & control; glycosaminoglycans; recurrence; venous thromboembolism; randomized controlled trial

Patients with a first episode of unprovoked venous thromboembolism have a high risk of recurrence after discontinuation of anticoagulant therapy. Extending anticoagulation reduces the risk of recurrence but is associated with increased bleeding. Sulodexide, a glycosaminoglycan, exerts antithrombotic...