Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

• Published in: Nature neuroscience Vol. 23; no. 10; pp. 1203 - 1214
• Main Authors: Marshall, Lee L., Killinger, Bryan A., Ensink, Elizabeth, Li, Peipei, Li, Katie X., Cui, Wei, Lubben, Noah, Weiland, Matthew, Wang, Xinhe, Gordevicius, Juozas, Coetzee, Gerhard A., Ma, Jiyan, Jovinge, Stefan, Labrie, Viviane
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2020; Nature Publishing Group
• Subjects: 13; 13/31; 13/51; 45; 45/23; 45/91; 631/208/176; 631/378/1689/1718; 64/60; Animal Genetics and Genomics; Animals; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Cytosine; Deactivation; Dioxygenases; DNA Methylation; DNA-Binding Proteins - genetics; Dopamine receptors; Enhancers; Epigenesis, Genetic; Epigenetics; Epigenomics; Female; Gene Expression Regulation; Genomes; Humans; Immune response; Inactivation; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Movement disorders; Neurobiology; Neurodegenerative diseases; Neurons; Neurons - metabolism; Neuroprotection; Neurosciences; Parkinson Disease - genetics; Parkinson's disease; Pathogenesis; Prefrontal Cortex - metabolism; Proto-Oncogene Proteins - genetics; Substantia nigra; Therapeutic targets; Up-regulation

Parkinson’s disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individuals. We find a widespread increase in cytosine modif...