Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective - Marshall, Lee L.; Killinger, Bryan A.; Ensink, Elizabeth; Li, Peipei; Li, Katie X.; Cui, Wei; Lubben, Noah; Weiland, Matthew; Wang, Xinhe; Gordevicius, Juozas; Coetzee, Gerhard A.; Ma, Jiyan; et al. (Nature neuroscience, 2020)
Keywords: 13; 13/31; 13/51; 45; 45/23; 45/91; 631/208/176; 631/378/1689/1718; 64/60; Animal Genetics and Genomics; Animals; Behavioral Sciences; Biological Techniques; Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Cytosine; Deactivation; Dioxygenases; DNA Methylation; DNA-Binding Proteins - genetics; Dopamine receptors; Enhancers; Epigenesis, Genetic; Epigenetics; Epigenomics; Female; Gene Expression Regulation; Genomes; Humans; Immune response; Inactivation; Inflammation; Male; Mice, Inbred C57BL; Mice, Knockout; Movement disorders; Neurobiology; Neurodegenerative diseases; Neurons; Neurons - metabolism; Neuroprotection; Neurosciences; Parkinson Disease - genetics; Parkinson's disease; Pathogenesis; Prefrontal Cortex - metabolism; Proto-Oncogene Proteins - genetics; Substantia nigra; Therapeutic targets; Up-regulation