Injectable, Manganese-Labeled Alginate Hydrogels as a Matrix for Longitudinal and Rapidly Retrievable 3D Cell Culture

• Published in: International journal of molecular sciences Vol. 26; no. 10; p. 4574
• Main Authors: Malysz-Cymborska, Izabela, Golubczyk, Dominika, Walczak, Piotr, Stanaszek, Luiza, Janowski, Miroslaw
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.05.2025; MDPI
• Subjects: Alginates - chemistry; Animals; Apoptosis; Cell culture; Cell Culture Techniques, Three Dimensional - methods; Cell Differentiation; Cell Proliferation; Cell Survival - drug effects; Cells, Cultured; Experiments; Hydrogels; Hydrogels - chemistry; Manganese - chemistry; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Metabolism; Mice; Solvents; Spinal cord; Stem cells; Swine; Transplants & implants; stem cells; 3D culture; injectable hydrogels; cell culture; contrast agents; cells recovery; dissolving of hydrogels; hydrogels; biomaterials; manganese

Hydrogels are one of the most attractive biomaterials, used in both three-dimensional (3D) and in vivo cultures. They facilitate the reconstruction of tissue microenvironments by preserving the spatial arrangement of cells, cell–cell interactions, and functional dynamics in the tissue. In this work,...