Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy

• Published in: Nature nanotechnology Vol. 13; no. 8; pp. 746 - 754
• Main Authors: Chiang, Chih-Sheng, Lin, Yu-Jung, Lee, Rachel, Lai, Yen-Ho, Cheng, Hung-Wei, Hsieh, Chia-Hung, Shyu, Woei-Cherng, Chen, San-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2018; Nature Publishing Group
• Subjects: 631/61/54/152; 639/925/352; 639/925/352/2733; Autoimmunity; CD28 antigen; CD3 antigen; Chemistry and Materials Science; Dextran; Dosage; Fucoidan; Immune checkpoint; Immunomodulation; Immunomodulators; Immunosuppression; Immunotherapy; Immunotoxicity; Lymphocytes; Lymphocytes T; Materials Science; Nanoparticles; Nanotechnology; Nanotechnology and Microengineering; Navigation; PD-L1 protein; Tumor microenvironment; Tumors

Checkpoint immunotherapy that inhibits tumour immune evasion has demonstrated significant clinical success. However, the therapeutic response is limited to certain patient populations, and immunotoxicity as well as autoimmunity have compromised the therapeutic benefits. Here, we report on an inheren...