Autism spectrum disorders pathogenesis: Toward a comprehensive model based on neuroanatomic and neurodevelopment considerations

• Published in: Frontiers in neuroscience Vol. 16; p. 988735
• Main Authors: Beopoulos, Athanasios, Géa, Manuel, Fasano, Alessio, Iris, François
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 03.11.2022
• Subjects: autism spectrum disorder (ASD); autonomic nervous system (ANS); maternal inflammation; neurodevelopment; Neuroscience; RNA editing; serotonin

Autism spectrum disorder (ASD) involves alterations in neural connectivity affecting cortical network organization and excitation to inhibition ratio. It is characterized by an early increase in brain volume mediated by abnormal cortical overgrowth patterns and by increases in size, spine density, a...