Evidence for the link between defective autophagy and inflammation in peripheral blood mononuclear cells of type 2 diabetic patients

• Published in: Journal of physiology and biochemistry Vol. 74; no. 3; pp. 369 - 379
• Main Authors: Alizadeh, Samira, Mazloom, Hossein, Sadeghi, Asie, Emamgholipour, Solaleh, Golestani, Abolfazl, Noorbakhsh, Farshid, Khoshniatnikoo, Mohsen, Meshkani, Reza
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.08.2018; Springer Nature B.V
• Subjects: Animal Physiology; Autophagy; Biomedical and Life Sciences; Biomedicine; Correlation; Cytokines; Diabetes; Diabetes mellitus; Gene expression; Human Physiology; Immune system; Inflammation; Interleukin 10; Leukocytes (mononuclear); Original Article; Patients; Peripheral blood mononuclear cells; Phagocytosis; Proteins; Real time; TOR protein; Transcription; Tumor necrosis factor-α; Type 2 diabetes; Peripheral blood mononuclear cells; mTOR; Inflammation; Autophagy; Cytokine

Autophagy was shown to modulate inflammation in immune cells. This study was designed to evaluate the association between autophagy and inflammation in peripheral blood mononuclear cells (PBMCs) of type 2 diabetic (T2D) and non-diabetic (ND) subjects. The autophagy markers were measured by real-time...