Transforming growth factor-β-mediated CD44/STAT3 signaling contributes to the development of atrial fibrosis and fibrillation

• Published in: Basic research in cardiology Vol. 112; no. 5; p. 58
• Main Authors: Chang, Shang-Hung, Yeh, Yung-Hsin, Lee, Jia-Lin, Hsu, Yu-Juei, Kuo, Chi-Tai, Chen, Wei-Jan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2017; Springer Nature B.V
• Subjects: Animals; Atria; Atrial Fibrillation - metabolism; Atrial Fibrillation - pathology; Atrial Fibrillation - physiopathology; Atrial Fibrillation - prevention & control; Atrial Remodeling; Cardiology; CD44 antigen; Cells, Cultured; Chromatin; Collagen; Collagen Type I - genetics; Collagen Type I - metabolism; Disease Models, Animal; Fibrillation; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Gene deletion; Growth factors; Heart Atria - metabolism; Heart Atria - pathology; Heart Atria - physiopathology; Heart Rate; Hyaluronan Receptors - genetics; Hyaluronan Receptors - metabolism; Hyaluronic acid; Hyaluronic Acid - metabolism; IgG antibody; Immunoglobulin G; Immunoprecipitation; Male; Medicine; Medicine & Public Health; Mice; Mice, Inbred DBA; Mice, Transgenic; Original Contribution; Pathogenesis; Plasmids; Rats, Wistar; Rhythm; Rodents; Signal Transduction; Sinus; Stat3 protein; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Stimulation; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b; Transgenic animals; Transgenic mice; Ventricle; Hyaluronan; Atrial fibrosis; Atrial fibrillation; Transforming growth factor-β; CD44

Atrial fibrillation (AF) is associated with atrial fibrosis. Inhibition of atrial fibrosis might be a plausible approach for AF prevention and therapy. This study is designed to evaluate the potential role of CD44, a membrane receptor known to regulate fibrosis, and its related signaling in the path...