Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case–control studies

• Published in: Genes and immunity Vol. 20; no. 6; pp. 484 - 492
• Main Authors: Zhang, Ming-Liang, Zhang, Dong-ming, Wang, Cai-E., Chen, Xiao-Long, Liu, Fang-Zhou, Yang, Jian-Xue
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2019; Nature Publishing Group
• Subjects: 38; 631/208/2489; 631/250/38; Alleles; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Female; Gene Expression; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Human Genetics; Humans; Immunology; Male; Meta-analysis; Polymorphism, Single Nucleotide; Risk Factors; Sensitivity analysis; Studies; Systematic review; Thyroglobulin; Thyroglobulin - genetics; Thyroid diseases; Thyroiditis, Autoimmune - ethnology; Thyroiditis, Autoimmune - etiology; Thyroiditis, Autoimmune - genetics

Emerging evidence revealed that thyroglobulin (TG) contributes to the development of autoimmune disease, and the relationship between TG and autoimmune thyroid disease (AITD) is still controversial. The aim of this study was to quantify the association between rs2076740 , rs853326 , rs180223 , and r...