Insights into inflammatory priming of mesenchymal stromal cells: functional biological impacts

• Published in: Inflammation research Vol. 67; no. 6; pp. 467 - 477
• Main Authors: Najar, Mehdi, Krayem, Mohammad, Merimi, Makram, Burny, Arsène, Meuleman, Nathalie, Bron, Dominique, Raicevic, Gordana, Lagneaux, Laurence
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2018; Springer Nature B.V
• Subjects: Allergology; Antigens; Biological properties; Biomedical and Life Sciences; Biomedicine; Cytokines; Dermatology; Empowerment; Genotype & phenotype; Immunology; Immunomodulation; Inflammation; Laboratories; Mesenchymal stem cells; Mesenchyme; Neurology; Pharmacology/Toxicology; Phenotypes; Priming; Review; Rheumatology; Stem cells; Stromal cells; Tumor necrosis factor-TNF; MSCs; Phenotype; Hematopoietic support; Multilineage potential; Immunomodulation; Priming; Inflammation

Mesenchymal stromal cells (MSCs) are multipotent adult cells with relevant biological properties making them interesting tools for cell-based therapy. These cells have the ability to home to sites of injury and secrete bioactive factors as part of their therapeutic functions. However, depending on t...