Variant angina associated with bitter orange in a dietary supplement

The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in advers...

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Bibliographic Details
Published inMayo Clinic proceedings Vol. 81; no. 4; pp. 545 - 548
Main Authors GANGE, Christopher A, MADIAS, Christopher, FELIX-GETZIK, Erika M, WEINTRAUB, Andrew R, ESTES, N. A. Mark
Format Journal Article
LanguageEnglish
Published Rochester, MN Mayo Medical Ventures 01.04.2006
Elsevier Limited
Subjects
Angina Pectoris, Variant - chemically induced
Angina Pectoris, Variant - diagnosis
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Diagnosis, Differential
Dietary Supplements - poisoning
Electrocardiography
General aspects
Heart
Humans
Male
Medical sciences
Middle Aged
Synephrine - poisoning
Vasoconstrictor Agents - poisoning
Medicine
Association
Cardiovascular disease
Supplementation
Coronary heart disease
Variant angina
Feeding
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Summary:The Food and Drug Administration has banned the sale of ephedrine-based weight-loss products because of their association with many cardiovascular adverse effects. Bitter orange is now being used as a stimulant in "ephedra-free" weight-loss supplements but was recently implicated in adverse cardiovascular sequelae. To our knowledge, this report describes the first case of variant angina associated with bitter orange in a dietary supplement.
ISSN:0025-6196
1942-5546
DOI:10.4065/81.4.545