White matter involvement in young non-demented Down’s syndrome subjects: a tract-based spatial statistic analysis

• Published in: Neuroradiology Vol. 60; no. 12; pp. 1335 - 1341
• Main Authors: Romano, Andrea, Moraschi, Marta, Cornia, Riccardo, Bozzao, Alessandro, Rossi-Espagnet, Maria Camilla, Giove, Federico, Albertini, Giorgio, Pierallini, Alberto
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2018; Springer Nature B.V
• Subjects: Adolescent; Adult; Amyloid; Brain Mapping; Cognitive ability; Computer programs; Control methods; Dementia disorders; Diffusion Tensor Imaging - methods; Down Syndrome - pathology; Down's syndrome; Female; Functional Neuroradiology; Handedness; Humans; Image acquisition; Image processing; Image Processing, Computer-Assisted; Imaging; Impact damage; Male; Medicine; Medicine & Public Health; Nerve Fibers, Myelinated - pathology; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Oxidative stress; Radiation; Radiology; Software; Spatial analysis; Substantia alba; Thalamus; White Matter - pathology; TBSS; Young; Down syndrome; White matter; Dementia

Purpose Cognitive decline in Down syndrome generally shows neurodegenerative aspects similar to what is observed in Alzheimer’s disease. Few studies reported information on white matter integrity. The aim of this study was to evaluate white matter alterations in a cohort of young Down subjects, with...