Glycine passivated Fe3O4 nanoparticles for thermal therapy

• Published in: Journal of colloid and interface science Vol. 369; no. 1; pp. 96 - 102
• Main Authors: Barick, K.C., Hassan, P.A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.03.2012; Elsevier
• Subjects: absorption; Amino acid coating; amino acids; Animals; Biomolecules; Cell Line; Chemistry; Colloidal state and disperse state; Colloids; Cytotoxicity; Exact sciences and technology; Ferric Compounds - chemistry; Ferric Compounds - therapeutic use; fever; General and physical chemistry; Glycine; Glycine - chemistry; Glycine - therapeutic use; HeLa Cells; Humans; Hyperthermia; Hyperthermia, Induced - methods; infrared spectroscopy; iron oxides; light scattering; magnetic fields; Magnetic particles; Magnetization; Mice; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Nanoparticles - ultrastructure; Physical and chemical studies. Granulometry. Electrokinetic phenomena; Surface charge; Surface chemistry; Synthetic aperture radar; therapeutics; Therapy; Cytotoxicity; Magnetic particles; Surface charge; Amino acid coating; Hyperthermia; External field; Binary compound; Stability; Magnetization; Nanoparticle; Light scattering; Transition element compounds; Glycine; Particle; Infrared spectrometry; Chemistry; Magnetite; Synthesis; Heating; Aminoacid; Thermal analysis; Magnetic field; Functional group; Passivation
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2011.12.008

[Display omitted] ► Biocompatible, water dispersible glycine passivated Fe3O4 nanoparticles. ► Carboxylate group is the preferable site for chemisorption of glycine with Fe3O4. ► Excellent heating ability under AC magnetic field shows its use in thermal therapy. ► Amine groups on Fe3O4 surface can be explored for conjugation of biomolecules. We demonstrate a single-step facile approach for the synthesis of glycine (amino acid) passivated Fe3O4 magnetic nanoparticles (GMNPs) using soft chemical route. The surface passivation of Fe3O4 nanoparticles with glycine molecules was evident from infrared spectroscopy, thermal and elemental analyses, and light scattering measurements. These nanoparticles show better colloidal stability, good magnetization, excellent self-heating capacity under external AC magnetic field and cytocompatibility with cell lines. Further, the active functional groups (–NH2) present on the surface of Fe3O4 nanoparticles can be accessible for routine conjugation of biomolecules/biolabelling through well-developed bioconjugation chemistry. Specifically, a new colloidal glycine passivated biocompatible Fe3O4 nanoparticles with excellent specific absorption rate (SAR) have been fabricated, which can be used as an effective heating source for hyperthermia treatment of cancer (thermal therapy).