Schizophrenia-Like Behaviors Arising from Dysregulated Proline Metabolism Are Associated with Altered Neuronal Morphology and Function in Mice with Hippocampal PRODH Deficiency

• Published in: Aging and disease Vol. 15; no. 4; pp. 1952 - 1968
• Main Authors: Yao, Yuxiao, Jin, Chenchen, Liao, Yilie, Huang, Xiang, Wei, Ziying, Zhang, Yahong, Li, Dongwei, Su, Huanxing, Han, Weiping, Qin, Dajiang
• Format: Journal Article
• Language: English
• Published: United States JKL International 01.08.2024; JKL International LLC
• Subjects: Amino acid metabolism, Inborn errors of; Animals; Behavior, Animal - physiology; Complications and side effects; Development and progression; Disease Models, Animal; Health aspects; Hippocampus (Brain); Hippocampus - metabolism; Hippocampus - pathology; Humans; Male; Mice; Mice, Knockout; Neurons; Neurons - metabolism; Neurons - pathology; Original; Oxidoreductases; Physiological aspects; Proline; Proline - genetics; Proline - metabolism; Proline Oxidase - deficiency; Proline Oxidase - genetics; Proline Oxidase - metabolism; Risk factors; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Schizophrenia - pathology; Social Behavior; China

Despite decades of research being conducted to understand what physiological deficits in the brain are an underlying basis of psychiatric diseases like schizophrenia, it has remained difficult to establish a direct causal relationship between neuronal dysfunction and specific behavioral phenotypes....