Mycobacterial crypto-AcpM as a tool to investigate the consequence of drug binding on its key FAS II partner enzyme HadAB

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 10; p. 129964
• Main Authors: Singh, Bina K., Biswas, Rupam, Basak, Amit, Das, Amit K.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2021
• Subjects: Acyl carrier protein; Crypto-ACP; drugs; enzymes; Fatty acid synthase-II; HadAB; Protein-protein interaction (PPI); protein-protein interactions; SPA0355; Thiacetazone; thiourea; Protein-protein interaction (PPI); SPA0355; Acyl carrier protein; HadAB; Fatty acid synthase-II; Thiacetazone; Crypto-ACP

Background Mycobacterial FASII pathway is governed by the Protein-Protein Interaction mediated dynamics existent between Acyl Carrier Protein and its partner enzymes. The dehydratase HadAB, involved in the third step of FASII synthesis has remained a key target of drugs like Thiacetazone (TAC) and i...