2,4-dinitrophenylhydrazine capturing combined with mass defect filtering strategy to identify aliphatic aldehydes in biological samples

• Published in: Journal of Chromatography A Vol. 1679; p. 463405
• Main Authors: Wang, Si-Yu, Liu, Hui, Zhu, Jin-Hao, Zhou, Shan-Shan, Xu, Jin-Di, Zhou, Jing, Mao, Qian, Kong, Ming, Li, Song-Lin, Zhu, He
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 30.08.2022
• Subjects: 2,4-dinitrophenylhydrazine; Aldehyde; blood serum; Characteristic ion; formalin; immunosuppression; Mass defect filtering; oxidative stress; toxicity; ultra-performance liquid chromatography; Mass defect filtering; Characteristic ion; 2,4-dinitrophenylhydrazine; Aldehyde

•A UPLC-QTOF-MS/MS strategy was developed to characterize aliphatic aldehydes.•The robust strategy was based on DNPH capturing combined MDF screening.•The characteristic ions of aldehyde-DNPHs were acquired by analyzing the references.•The strategy was validated to identify aliphatic aldehydes in bi...