Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (L...

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Published inJournal of thrombosis and thrombolysis Vol. 37; no. 4; pp. 455 - 463
Main Authors Zhang, Xuguang, McGeoch, Susan C., Johnstone, Alexandra M., Holtrop, Grietje, Sneddon, Alan A., MacRury, Sandra M., Megson, Ian L., Pearson, Donald W. M., Abraham, Prakash, De Roos, Baukje, Lobley, Gerald E., O’Kennedy, Niamh
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.05.2014
Springer Nature B.V
Subjects
Adult
Aged
Atherosclerosis - blood
Atherosclerosis - etiology
Biomarkers - blood
Blood Platelets
Cardiology
Cell-Derived Microparticles - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetic Angiopathies - blood
Female
Hematology
Humans
Leukocyte Count
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity - blood
Platelet Activation
Risk Factors
Obesity
Circulating cell-derived microparticles
Type 2 diabetes mellitus
Blood platelets
Cardiovascular diseases
Online AccessGet full text
ISSN0929-5305
1573-742X
1573-742X
DOI10.1007/s11239-013-1000-2

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Abstract This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP ( P  = 0.003), and PMP that were fibrinogen-positive ( P  = 0.04), tissue factor-positive ( P  < 0.001), P-selectin-positive ( P  = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.
AbstractList This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.
This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP ( P  = 0.003), and PMP that were fibrinogen-positive ( P  = 0.04), tissue factor-positive ( P  < 0.001), P-selectin-positive ( P  = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.
This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.
This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.[PUBLICATION ABSTRACT]
Author Megson, Ian L.
MacRury, Sandra M.
Johnstone, Alexandra M.
Holtrop, Grietje
McGeoch, Susan C.
Abraham, Prakash
Zhang, Xuguang
Sneddon, Alan A.
De Roos, Baukje
O’Kennedy, Niamh
Pearson, Donald W. M.
Lobley, Gerald E.
Author_xml – sequence: 1
  givenname: Xuguang
  surname: Zhang
  fullname: Zhang, Xuguang
  organization: Rowett Institute of Nutrition and Health, University of Aberdeen
– sequence: 2
  givenname: Susan C.
  surname: McGeoch
  fullname: McGeoch, Susan C.
  organization: Department of Diabetes, Aberdeen Royal Infirmary
– sequence: 3
  givenname: Alexandra M.
  surname: Johnstone
  fullname: Johnstone, Alexandra M.
  organization: Rowett Institute of Nutrition and Health, University of Aberdeen
– sequence: 4
  givenname: Grietje
  surname: Holtrop
  fullname: Holtrop, Grietje
  organization: Biomathematics and Statistics Scotland, Rowett Institute of Nutrition & Health
– sequence: 5
  givenname: Alan A.
  surname: Sneddon
  fullname: Sneddon, Alan A.
  organization: Rowett Institute of Nutrition and Health, University of Aberdeen
– sequence: 6
  givenname: Sandra M.
  surname: MacRury
  fullname: MacRury, Sandra M.
  organization: Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands
– sequence: 7
  givenname: Ian L.
  surname: Megson
  fullname: Megson, Ian L.
  organization: Department of Diabetes and Cardiovascular Science, University of the Highlands and Islands
– sequence: 8
  givenname: Donald W. M.
  surname: Pearson
  fullname: Pearson, Donald W. M.
  organization: Department of Diabetes, Aberdeen Royal Infirmary
– sequence: 9
  givenname: Prakash
  surname: Abraham
  fullname: Abraham, Prakash
  organization: Department of Diabetes, Aberdeen Royal Infirmary
– sequence: 10
  givenname: Baukje
  surname: De Roos
  fullname: De Roos, Baukje
  organization: Rowett Institute of Nutrition and Health, University of Aberdeen
– sequence: 11
  givenname: Gerald E.
  surname: Lobley
  fullname: Lobley, Gerald E.
  organization: Rowett Institute of Nutrition and Health, University of Aberdeen
– sequence: 12
  givenname: Niamh
  surname: O’Kennedy
  fullname: O’Kennedy, Niamh
  email: niamh.okennedy@provexis.com
  organization: Provexis Plc, c/o University of Aberdeen, Rowett Institute of Nutrition & Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24097206$$D View this record in MEDLINE/PubMed
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Cites_doi 10.2741/1466
10.1017/S0007114511000092
10.1161/01.ATV.0000249639.36915.04
10.1016/j.thromres.2010.01.035
10.1016/j.amjcard.2006.01.054
10.1111/j.1538-7836.2004.00941.x
10.1146/annurev-immunol-031210-101322
10.1111/j.1464-5491.2005.01707.x
10.1080/09537100802054107
10.1038/sj.ijo.0801938
10.3324/haematol.2013.083808
10.3324/haematol.2012.066167
10.1016/j.thromres.2010.07.006
10.1177/1076029611405032
10.1373/clinchem.2005.057414
10.1097/MCO.0b013e32832c6db7
10.1016/S0008-6363(03)00367-5
10.1080/09537100701817232
10.1080/09537100600864285
10.1161/01.CIR.97.21.2099
10.1093/eurheartj/ehi746
10.1080/00207230500120401
10.1002/ana.21681
10.1161/01.CIR.102.14.1634
10.1038/jhh.2008.138
10.1378/chest.124.3_suppl.4S
10.1532/IJH97.03167
10.1016/j.ehj.2003.08.021
10.1161/01.CIR.101.8.841
10.2337/diabetes.51.9.2840
10.1172/JCI27196
10.1016/j.thromres.2005.12.013
10.1161/01.HYP.0000231507.00962.b5
10.1016/j.thromres.2009.10.006
10.1111/j.1538-7836.2005.01780.x
10.1681/ASN.2005050535
10.1007/s00125-001-0772-7
10.1016/S1262-3636(07)70251-3
10.1161/01.CIR.0000036596.59665.C6
10.1016/j.vph.2011.03.005
10.1016/S0049-3848(02)00334-1
10.1007/s10544-012-9642-y
10.1182/blood.V94.11.3791
10.1182/blood.V93.3.876
10.1160/TH07-10-0602
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IsPeerReviewed true
IsScholarly true
Issue 4
Keywords Obesity
Circulating cell-derived microparticles
Type 2 diabetes mellitus
Blood platelets
Cardiovascular diseases
Language English
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PublicationSubtitle A Journal for Translation, Application and Therapeutics in Thrombosis and Vascular Science
PublicationTitle Journal of thrombosis and thrombolysis
PublicationTitleAbbrev J Thromb Thrombolysis
PublicationTitleAlternate J Thromb Thrombolysis
PublicationYear 2014
Publisher Springer US
Springer Nature B.V
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References Evangelista, Manarini, Sideri, Rotondo (CR38) 1999; 93
Diamant, Nieuwland, Pablo, Sturk (CR34) 2002; 106
Arteaga, Chirinos, Soriano, Jy (CR44) 2006; 98
Garcia Rodriguez, Eikenboom, Tesselaar, Huisman (CR1) 2010; 126
Jung, Chu, Lee, Park (CR17) 2009; 66
Wildman (CR27) 2009; 12
Omoto, Nomura, Shouzu, Nishikawa (CR48) 2002; 45
CR32
Sabatier, Darmon, Hugel, Combes (CR13) 2002; 51
Blann, Nadar, Lip (CR39) 2003; 24
Morel, Ohlmann, Morel, Jesel (CR7) 2005; 98
Lacroix, Plawinski, Robert, Doeuvre (CR50) 2012; 97
Amabile, Guerin, Leroyer, Mallat (CR8) 2005; 16
Shantsila (CR16) 2009; 23
Goichot, Grunebaum, Desprez, Vinzio (CR23) 2006; 32
Chironi, Simon, Hugel, Del Pino (CR46) 2006; 26
Langer, Chavakis (CR45) 2009; 13
Gregor, Hotamisligil (CR22) 2011; 29
Toth, Liebhardt, Steinig, Ditsch (CR14) 2008; 100
Mann (CR35) 2003; 124
Tan, Tayebjee, Lim, Lip (CR10) 2005; 22
Heijnen, Schiel, Fijnheer, Geuze, Sixma (CR25) 1999; 94
Key (CR33) 2010; 125
Morrissey (CR36) 2004; 79
Kumanyika, Jeffery, Morabia, Ritenbaugh (CR19) 2002; 26
Johnstone, Lobley, Horgan, Bremner (CR43) 2011; 106
Cohen, Gonzales, Davis-Gorman, Copeland, McDonagh (CR18) 2002; 107
Tan, Tayebjee, Macfadyen, Lip, Blann (CR11) 2005; 16
Shah, Bergeron, Dong, Lopez (CR3) 2008; 19
Madonna, De Caterina (CR42) 2011; 54
Boulanger, Amabile, Tedgui (CR15) 2006; 48
Murakami, Horigome, Tanaka, Nakata (CR29) 2007; 119
Lok, Nieuwland, Sturk, Hau (CR41) 2007; 18
VanWijk, VanBavel, Sturk, Nieuwland (CR37) 2003; 59
Ramacciotti, Blackburn, Hawley, Vandy (CR24) 2011; 17
(CR21) 1998; 6
Patil, Ghosh, Shetty (CR49) 2013; 98
Faure, Dou, Sabatier, Cerini (CR4) 2006; 4
Mobarrez, Antovic, Egberg, Hansson (CR6) 2010; 125
Stec, Silbershatz, Tofler, Matheney (CR31) 2000; 102
van der Zee, Biro, Ko, de Winter (CR40) 2006; 52
CR28
Gawaz, Langer, May (CR30) 2005; 115
Koga, Sugiyama, Kugiyama, Fukushima (CR9) 2006; 27
Eckel, Krauss (CR20) 1998; 97
Jy, Minagar, Jimenez, Sheremata (CR12) 2004; 9
Morel, Morel, Freyssinet, Toti (CR5) 2008; 19
Mallat, Benamer, Hugel, Benessiano (CR47) 2000; 101
Shet, Key, Hebbel (CR2) 2004; 2
Ashcroft, Sonneville, Yuana, Osanto (CR26) 2012; 14
R Lacroix (1000_CR50) 2012; 97
B Toth (1000_CR14) 2008; 100
Z Cohen (1000_CR18) 2002; 107
HF Langer (1000_CR45) 2009; 13
O Morel (1000_CR5) 2008; 19
MF Gregor (1000_CR22) 2011; 29
PM Zee van der (1000_CR40) 2006; 52
KT Tan (1000_CR10) 2005; 22
M Diamant (1000_CR34) 2002; 106
NS Key (1000_CR33) 2010; 125
G Chironi (1000_CR46) 2006; 26
AM Johnstone (1000_CR43) 2011; 106
R Madonna (1000_CR42) 2011; 54
M Gawaz (1000_CR30) 2005; 115
S Omoto (1000_CR48) 2002; 45
T Murakami (1000_CR29) 2007; 119
O Morel (1000_CR7) 2005; 98
S Kumanyika (1000_CR19) 2002; 26
AD Blann (1000_CR39) 2003; 24
MD Shah (1000_CR3) 2008; 19
R Patil (1000_CR49) 2013; 98
CA Lok (1000_CR41) 2007; 18
JJ Stec (1000_CR31) 2000; 102
V Evangelista (1000_CR38) 1999; 93
1000_CR32
MJ VanWijk (1000_CR37) 2003; 59
E Shantsila (1000_CR16) 2009; 23
E Ramacciotti (1000_CR24) 2011; 17
P Garcia Rodriguez (1000_CR1) 2010; 126
RB Arteaga (1000_CR44) 2006; 98
KG Mann (1000_CR35) 2003; 124
JH Morrissey (1000_CR36) 2004; 79
W Jy (1000_CR12) 2004; 9
AS Shet (1000_CR2) 2004; 2
1000_CR28
KH Jung (1000_CR17) 2009; 66
F Mobarrez (1000_CR6) 2010; 125
1000_CR26
KT Tan (1000_CR11) 2005; 16
V Faure (1000_CR4) 2006; 4
1000_CR21
H Koga (1000_CR9) 2006; 27
F Sabatier (1000_CR13) 2002; 51
HF Heijnen (1000_CR25) 1999; 94
Z Mallat (1000_CR47) 2000; 101
N Amabile (1000_CR8) 2005; 16
RP Wildman (1000_CR27) 2009; 12
RH Eckel (1000_CR20) 1998; 97
CM Boulanger (1000_CR15) 2006; 48
B Goichot (1000_CR23) 2006; 32
References_xml – volume: 9
  start-page: 3137
  year: 2004
  end-page: 3144
  ident: CR12
  article-title: Endothelial microparticles (EMP) bind and activate monocytes: elevated EMP-monocyte conjugates in multiple sclerosis
  publication-title: Front Biosci
  doi: 10.2741/1466
– volume: 106
  start-page: 1
  issue: 2
  year: 2011
  end-page: 10
  ident: CR43
  article-title: Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile
  publication-title: Br J Nutr
  doi: 10.1017/S0007114511000092
– volume: 26
  start-page: 2775
  year: 2006
  end-page: 2780
  ident: CR46
  article-title: Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000249639.36915.04
– volume: 93
  start-page: 876
  year: 1999
  end-page: 885
  ident: CR38
  article-title: Platelet/polymorphonuclear leukocyte interaction: p-selectin triggers protein-tyrosine phosphorylation-dependent CD11b/CD18 adhesion: role of PSGL-1 as a signaling molecule
  publication-title: Blood
– volume: 125
  start-page: S42
  issue: Suppl 1
  year: 2010
  end-page: S45
  ident: CR33
  article-title: Analysis of tissue factor positive microparticles
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2010.01.035
– volume: 98
  start-page: 70
  year: 2006
  end-page: 74
  ident: CR44
  article-title: Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2006.01.054
– volume: 2
  start-page: 1848
  year: 2004
  end-page: 1850
  ident: CR2
  article-title: Measuring circulating cell-derived microparticles
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2004.00941.x
– volume: 29
  start-page: 415
  year: 2011
  end-page: 445
  ident: CR22
  article-title: Inflammatory mechanisms in obesity
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-031210-101322
– volume: 22
  start-page: 1657
  year: 2005
  end-page: 1662
  ident: CR10
  article-title: Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels
  publication-title: Diabet Med
  doi: 10.1111/j.1464-5491.2005.01707.x
– volume: 19
  start-page: 365
  year: 2008
  end-page: 372
  ident: CR3
  article-title: Flow cytometric measurement of microparticles: pitfalls and protocol modifications
  publication-title: Platelets
  doi: 10.1080/09537100802054107
– volume: 26
  start-page: 425
  year: 2002
  end-page: 436
  ident: CR19
  article-title: Obesity prevention: the case for action
  publication-title: Int J Obes Relat Metab Disord
  doi: 10.1038/sj.ijo.0801938
– volume: 98
  start-page: e69
  year: 2013
  ident: CR49
  article-title: Profibrinolytic microparticles are not adequately produced to compensate their prothrombotic effect
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.083808
– volume: 97
  start-page: 1864
  year: 2012
  end-page: 1872
  ident: CR50
  article-title: Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis
  publication-title: Haematologica
  doi: 10.3324/haematol.2012.066167
– volume: 126
  start-page: 345
  year: 2010
  end-page: 349
  ident: CR1
  article-title: Plasma levels of microparticle-associated tissue factor activity in patients with clinically suspected pulmonary embolism
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2010.07.006
– volume: 100
  start-page: 663
  year: 2008
  end-page: 669
  ident: CR14
  article-title: Platelet-derived microparticles and coagulation activation in breast cancer patients
  publication-title: Thromb Haemost
– volume: 17
  start-page: 425
  year: 2011
  end-page: 431
  ident: CR24
  article-title: Evaluation of soluble P-selectin as a marker for the diagnosis of deep venous thrombosis
  publication-title: Clin Appl Thromb Hemost
  doi: 10.1177/1076029611405032
– volume: 6
  start-page: 51S
  issue: Suppl 2
  year: 1998
  end-page: 209S
  ident: CR21
  article-title: National Institutes of Health
  publication-title: Obes Res
– volume: 52
  start-page: 657
  year: 2006
  end-page: 664
  ident: CR40
  article-title: P-selectin- and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction
  publication-title: Clin Chem
  doi: 10.1373/clinchem.2005.057414
– volume: 14
  start-page: 641
  issue: 4
  year: 2012
  end-page: 649
  ident: CR26
  article-title: Determination of the size distribution of blood microparticles directly in plasma using atomic force microscopy and microfluidics
  publication-title: Biomed Microdevices
– volume: 12
  start-page: 438
  year: 2009
  end-page: 443
  ident: CR27
  article-title: Healthy obesity
  publication-title: Curr Opin Clin Nutr Metab Care
  doi: 10.1097/MCO.0b013e32832c6db7
– volume: 59
  start-page: 277
  year: 2003
  end-page: 287
  ident: CR37
  article-title: Microparticles in cardiovascular diseases
  publication-title: Cardiovasc Res
  doi: 10.1016/S0008-6363(03)00367-5
– volume: 19
  start-page: 9
  year: 2008
  end-page: 23
  ident: CR5
  article-title: Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses
  publication-title: Platelets
  doi: 10.1080/09537100701817232
– ident: CR32
– volume: 18
  start-page: 68
  year: 2007
  end-page: 72
  ident: CR41
  article-title: Microparticle-associated P-selectin reflects platelet activation in preeclampsia
  publication-title: Platelets
  doi: 10.1080/09537100600864285
– volume: 97
  start-page: 2099
  year: 1998
  end-page: 2100
  ident: CR20
  article-title: American Heart Association call to action: obesity as a major risk factor for coronary heart disease
  publication-title: AHA Nutrition Committee.Circulation
  doi: 10.1161/01.CIR.97.21.2099
– volume: 27
  start-page: 817
  year: 2006
  end-page: 823
  ident: CR9
  article-title: Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehi746
– volume: 16
  start-page: 368
  year: 2005
  end-page: 371
  ident: CR11
  article-title: Elevated platelet microparticles in stable coronary artery disease are unrelated to disease severity or to indices of inflammation
  publication-title: Platelets
  doi: 10.1080/00207230500120401
– volume: 66
  start-page: 191
  year: 2009
  end-page: 199
  ident: CR17
  article-title: Circulating endothelial microparticles as a marker of cerebrovascular disease
  publication-title: Ann Neurol
  doi: 10.1002/ana.21681
– volume: 102
  start-page: 1634
  year: 2000
  end-page: 1638
  ident: CR31
  article-title: Association of fibrinogen with cardiovascular risk factors and cardiovascular disease in the Framingham Offspring Population
  publication-title: Circulation
  doi: 10.1161/01.CIR.102.14.1634
– volume: 23
  start-page: 359
  year: 2009
  end-page: 361
  ident: CR16
  article-title: Endothelial microparticles: a universal marker of vascular health?
  publication-title: J Hum Hypertens
  doi: 10.1038/jhh.2008.138
– volume: 124
  start-page: 4S
  year: 2003
  end-page: 10S
  ident: CR35
  article-title: Thrombin formation
  publication-title: Chest
  doi: 10.1378/chest.124.3_suppl.4S
– volume: 79
  start-page: 103
  year: 2004
  end-page: 108
  ident: CR36
  article-title: Tissue factor: a key molecule in hemostatic and nonhemostatic systems
  publication-title: Int J Hematol
  doi: 10.1532/IJH97.03167
– volume: 24
  start-page: 2166
  year: 2003
  end-page: 2179
  ident: CR39
  article-title: The adhesion molecule P-selectin and cardiovascular disease
  publication-title: Eur Heart J
  doi: 10.1016/j.ehj.2003.08.021
– volume: 101
  start-page: 841
  year: 2000
  end-page: 843
  ident: CR47
  article-title: Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes
  publication-title: Circulation
  doi: 10.1161/01.CIR.101.8.841
– volume: 51
  start-page: 2840
  year: 2002
  end-page: 2845
  ident: CR13
  article-title: Type 1 and type 2 diabetic patients display different patterns of cellular microparticles
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.9.2840
– volume: 115
  start-page: 3378
  year: 2005
  end-page: 3384
  ident: CR30
  article-title: Platelets in inflammation and atherogenesis
  publication-title: J Clin Invest
  doi: 10.1172/JCI27196
– volume: 119
  start-page: 45
  year: 2007
  end-page: 53
  ident: CR29
  article-title: Impact of weight reduction on production of platelet-derived microparticles and fibrinolytic parameters in obesity
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2005.12.013
– volume: 48
  start-page: 180
  year: 2006
  end-page: 186
  ident: CR15
  article-title: Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000231507.00962.b5
– volume: 125
  start-page: e110
  year: 2010
  end-page: e116
  ident: CR6
  article-title: A multicolor flow cytometric assay for measurement of platelet-derived microparticles
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2009.10.006
– volume: 4
  start-page: 566
  year: 2006
  end-page: 573
  ident: CR4
  article-title: Elevation of circulating endothelial microparticles in patients with chronic renal failure
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2005.01780.x
– volume: 16
  start-page: 3381
  year: 2005
  end-page: 3388
  ident: CR8
  article-title: Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2005050535
– volume: 45
  start-page: 550
  year: 2002
  end-page: 555
  ident: CR48
  article-title: Detection of monocyte-derived microparticles in patients with type II diabetes mellitus
  publication-title: Diabetologia
  doi: 10.1007/s00125-001-0772-7
– volume: 94
  start-page: 3791
  year: 1999
  end-page: 3799
  ident: CR25
  article-title: Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules
  publication-title: Blood
– volume: 98
  start-page: 226
  year: 2005
  end-page: 235
  ident: CR7
  article-title: Microparticles and cardiovascular disease
  publication-title: Arch Mal Coeur Vaiss
– volume: 32
  start-page: 82
  year: 2006
  end-page: 85
  ident: CR23
  article-title: Circulating procoagulant microparticles in obesity
  publication-title: Diabetes Metab
  doi: 10.1016/S1262-3636(07)70251-3
– volume: 106
  start-page: 2442
  year: 2002
  end-page: 2447
  ident: CR34
  article-title: Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000036596.59665.C6
– volume: 13
  start-page: 1211
  year: 2009
  end-page: 1220
  ident: CR45
  article-title: Leukocyte-endothelial interactions in inflammation
  publication-title: J Cell
– volume: 54
  start-page: 68
  year: 2011
  end-page: 74
  ident: CR42
  article-title: Cellular and molecular mechanisms of vascular injury in diabetes—part I: pathways of vascular disease in diabetes
  publication-title: Vascul Pharmacol
  doi: 10.1016/j.vph.2011.03.005
– volume: 107
  start-page: 217
  year: 2002
  end-page: 221
  ident: CR18
  article-title: Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation
  publication-title: Thromb Res
  doi: 10.1016/S0049-3848(02)00334-1
– ident: CR28
– volume: 59
  start-page: 277
  year: 2003
  ident: 1000_CR37
  publication-title: Cardiovasc Res
  doi: 10.1016/S0008-6363(03)00367-5
– volume: 16
  start-page: 368
  year: 2005
  ident: 1000_CR11
  publication-title: Platelets
  doi: 10.1080/00207230500120401
– volume: 23
  start-page: 359
  year: 2009
  ident: 1000_CR16
  publication-title: J Hum Hypertens
  doi: 10.1038/jhh.2008.138
– volume: 54
  start-page: 68
  year: 2011
  ident: 1000_CR42
  publication-title: Vascul Pharmacol
  doi: 10.1016/j.vph.2011.03.005
– volume: 16
  start-page: 3381
  year: 2005
  ident: 1000_CR8
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2005050535
– volume: 22
  start-page: 1657
  year: 2005
  ident: 1000_CR10
  publication-title: Diabet Med
  doi: 10.1111/j.1464-5491.2005.01707.x
– volume: 29
  start-page: 415
  year: 2011
  ident: 1000_CR22
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-031210-101322
– volume: 101
  start-page: 841
  year: 2000
  ident: 1000_CR47
  publication-title: Circulation
  doi: 10.1161/01.CIR.101.8.841
– volume: 2
  start-page: 1848
  year: 2004
  ident: 1000_CR2
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2004.00941.x
– volume: 52
  start-page: 657
  year: 2006
  ident: 1000_CR40
  publication-title: Clin Chem
  doi: 10.1373/clinchem.2005.057414
– volume: 126
  start-page: 345
  year: 2010
  ident: 1000_CR1
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2010.07.006
– ident: 1000_CR28
– volume: 115
  start-page: 3378
  year: 2005
  ident: 1000_CR30
  publication-title: J Clin Invest
  doi: 10.1172/JCI27196
– volume: 24
  start-page: 2166
  year: 2003
  ident: 1000_CR39
  publication-title: Eur Heart J
  doi: 10.1016/j.ehj.2003.08.021
– volume: 97
  start-page: 1864
  year: 2012
  ident: 1000_CR50
  publication-title: Haematologica
  doi: 10.3324/haematol.2012.066167
– volume: 9
  start-page: 3137
  year: 2004
  ident: 1000_CR12
  publication-title: Front Biosci
  doi: 10.2741/1466
– volume: 51
  start-page: 2840
  year: 2002
  ident: 1000_CR13
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.9.2840
– volume: 106
  start-page: 1
  issue: 2
  year: 2011
  ident: 1000_CR43
  publication-title: Br J Nutr
  doi: 10.1017/S0007114511000092
– volume: 48
  start-page: 180
  year: 2006
  ident: 1000_CR15
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000231507.00962.b5
– volume: 26
  start-page: 425
  year: 2002
  ident: 1000_CR19
  publication-title: Int J Obes Relat Metab Disord
  doi: 10.1038/sj.ijo.0801938
– volume: 106
  start-page: 2442
  year: 2002
  ident: 1000_CR34
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000036596.59665.C6
– volume: 98
  start-page: e69
  year: 2013
  ident: 1000_CR49
  publication-title: Haematologica
  doi: 10.3324/haematol.2013.083808
– volume: 19
  start-page: 365
  year: 2008
  ident: 1000_CR3
  publication-title: Platelets
  doi: 10.1080/09537100802054107
– ident: 1000_CR26
  doi: 10.1007/s10544-012-9642-y
– volume: 124
  start-page: 4S
  year: 2003
  ident: 1000_CR35
  publication-title: Chest
  doi: 10.1378/chest.124.3_suppl.4S
– volume: 98
  start-page: 226
  year: 2005
  ident: 1000_CR7
  publication-title: Arch Mal Coeur Vaiss
– volume: 79
  start-page: 103
  year: 2004
  ident: 1000_CR36
  publication-title: Int J Hematol
  doi: 10.1532/IJH97.03167
– volume: 102
  start-page: 1634
  year: 2000
  ident: 1000_CR31
  publication-title: Circulation
  doi: 10.1161/01.CIR.102.14.1634
– volume: 45
  start-page: 550
  year: 2002
  ident: 1000_CR48
  publication-title: Diabetologia
  doi: 10.1007/s00125-001-0772-7
– volume: 12
  start-page: 438
  year: 2009
  ident: 1000_CR27
  publication-title: Curr Opin Clin Nutr Metab Care
  doi: 10.1097/MCO.0b013e32832c6db7
– volume: 18
  start-page: 68
  year: 2007
  ident: 1000_CR41
  publication-title: Platelets
  doi: 10.1080/09537100600864285
– volume: 98
  start-page: 70
  year: 2006
  ident: 1000_CR44
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2006.01.054
– volume: 94
  start-page: 3791
  year: 1999
  ident: 1000_CR25
  publication-title: Blood
  doi: 10.1182/blood.V94.11.3791
– volume: 32
  start-page: 82
  year: 2006
  ident: 1000_CR23
  publication-title: Diabetes Metab
  doi: 10.1016/S1262-3636(07)70251-3
– volume: 125
  start-page: S42
  issue: Suppl 1
  year: 2010
  ident: 1000_CR33
  publication-title: Thromb Res
– volume: 27
  start-page: 817
  year: 2006
  ident: 1000_CR9
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehi746
– volume: 97
  start-page: 2099
  year: 1998
  ident: 1000_CR20
  publication-title: AHA Nutrition Committee.Circulation
  doi: 10.1161/01.CIR.97.21.2099
– volume: 93
  start-page: 876
  year: 1999
  ident: 1000_CR38
  publication-title: Blood
  doi: 10.1182/blood.V93.3.876
– volume: 4
  start-page: 566
  year: 2006
  ident: 1000_CR4
  publication-title: J Thromb Haemost
  doi: 10.1111/j.1538-7836.2005.01780.x
– volume: 19
  start-page: 9
  year: 2008
  ident: 1000_CR5
  publication-title: Platelets
  doi: 10.1080/09537100701817232
– volume: 100
  start-page: 663
  year: 2008
  ident: 1000_CR14
  publication-title: Thromb Haemost
  doi: 10.1160/TH07-10-0602
– ident: 1000_CR32
– volume: 26
  start-page: 2775
  year: 2006
  ident: 1000_CR46
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000249639.36915.04
– volume: 125
  start-page: e110
  year: 2010
  ident: 1000_CR6
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2009.10.006
– volume: 107
  start-page: 217
  year: 2002
  ident: 1000_CR18
  publication-title: Thromb Res
  doi: 10.1016/S0049-3848(02)00334-1
– volume: 119
  start-page: 45
  year: 2007
  ident: 1000_CR29
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2005.12.013
– volume: 66
  start-page: 191
  year: 2009
  ident: 1000_CR17
  publication-title: Ann Neurol
  doi: 10.1002/ana.21681
– ident: 1000_CR21
– volume: 17
  start-page: 425
  year: 2011
  ident: 1000_CR24
  publication-title: Clin Appl Thromb Hemost
  doi: 10.1177/1076029611405032
– volume: 13
  start-page: 1211
  year: 2009
  ident: 1000_CR45
  publication-title: J Cell
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Snippet This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the...
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SubjectTerms Adult
Aged
Atherosclerosis - blood
Atherosclerosis - etiology
Biomarkers - blood
Blood Platelets
Cardiology
Cell-Derived Microparticles - metabolism
Diabetes Mellitus, Type 2 - blood
Diabetic Angiopathies - blood
Female
Hematology
Humans
Leukocyte Count
Male
Medicine
Medicine & Public Health
Middle Aged
Obesity - blood
Platelet Activation
Risk Factors
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Title Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status
URI https://link.springer.com/article/10.1007/s11239-013-1000-2
https://www.ncbi.nlm.nih.gov/pubmed/24097206
https://www.proquest.com/docview/1515459607
https://www.proquest.com/docview/1516398368
Volume 37
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