Modeling Human Cardiac Thin Filament Structures

• Published in: Frontiers in physiology Vol. 13; p. 932333
• Main Authors: Rynkiewicz, Michael J., Pavadai, Elumalai, Lehman, William
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.06.2022
• Subjects: actin; cryoEM; Physiology; protein-protein docking; tropomyosin; troponin

Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments. Tropomyosin/troponin sterically blocks myosin-binding at low-calcium concentrations but moves t...