TKF, a mexicanolide-type limonoid derivative, suppressed hepatic stellate cells activation and liver fibrosis through inhibition of the YAP/Notch3 pathway

• Published in: Phytomedicine (Stuttgart) Vol. 107; p. 154466
• Main Authors: Yang, Ting, Wu, Enyi, Zhu, Xiaoyun, Leng, Yingrong, Ye, Shengtao, Dong, Ruirui, Liu, Jiaman, Zhong, Jiawen, Zheng, Ying, Xu, Wenjun, Luo, Jun, Kong, Lingyi, Zhang, Hao
• Format: Journal Article
• Language: English
• Published: Elsevier GmbH 01.12.2022
• Subjects: bile ducts; collagen; drugs; fibrosis; gene expression; Hepatic stellate cells; histopathology; humans; limonoids; liver cirrhosis; Liver fibrosis; liver neoplasms; mice; Notch3; therapeutics; TKF; Yap; AST; H&E; Yap; ALT; Liver fibrosis; BDL; TKF; COL1A1; Notch3; CCl4; αSMA; Hepatic stellate cells; TGF-β1; HSCs; NICD3

Liver fibrosis is a common scarring response and may ultimately lead to liver cancer, unfortunately, there is currently no effective antifibrotic drug approved for human use. Limonoids exhibit a broad spectrum of biological activities; however, the potential role of limonoids against fibrosis is lar...