TKF, a mexicanolide-type limonoid derivative, suppressed hepatic stellate cells activation and liver fibrosis through inhibition of the YAP/Notch3 pathway - Yang, Ting; Wu, Enyi; Zhu, Xiaoyun; Leng, Yingrong; Ye, Shengtao; Dong, Ruirui; Liu, Jiaman; Zhong, Jiawen; Zheng, Ying; Xu, Wenjun; Luo, Jun; Kong, Lingyi; et al. (Phytomedicine (Stuttgart), 2022)
Keywords: bile ducts; collagen; drugs; fibrosis; gene expression; Hepatic stellate cells; histopathology; humans; limonoids; liver cirrhosis; Liver fibrosis; liver neoplasms; mice; Notch3; therapeutics; TKF; Yap; AST; H&E; Yap; ALT; Liver fibrosis; BDL; TKF; COL1A1; Notch3; CCl4; αSMA; Hepatic stellate cells; TGF-β1; HSCs; NICD3