Metformin suppresses proliferation and differentiation induced by BMP9 via AMPK signaling in human fetal lung fibroblast-1

• Published in: Frontiers in pharmacology Vol. 13; p. 984730
• Main Authors: Chen, Qiongfeng, Wang, Yaqun, Sheng, Linna, Huang, Yonghong
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.08.2022
• Subjects: AMPK; BMP9; differentiation; lung fibroblast; metformin; Pharmacology; proliferation

Adenosine monophosphosphate-activated protein kinase (AMPK) and its activator metformin were found to be involved in the regulation of fibroblast activation and pulmonary fibrosis. However, the regulatory mechanism has been undetermined. Recently, AMPK has been reported to exert its effect through i...