Early changes to the extracellular space in the hippocampus under simulated microgravity conditions

• Published in: Science China. Life sciences Vol. 65; no. 3; pp. 604 - 617
• Main Authors: Gao, Yajuan, Han, Hongbin, Du, Jichen, He, Qingyuan, Jia, Yanxing, Yan, Junhao, Dai, Hui, Cui, Bin, Yang, Jing, Wei, Xunbin, Yang, Liu, Wang, Rui, Long, Ren, Ren, Qiushi, Yang, Xing, Lu, Jiabin
• Format: Journal Article
• Language: English
• Published: Beijing Science China Press 01.03.2022; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Drainage; Extracellular Fluid; Extracellular matrix; Extracellular Space - diagnostic imaging; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - pathology; Life Sciences; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Microgravity; Neuroimaging; Neuroprotection; Rats; Rats, Sprague-Dawley; Research Paper; Unloading; Weightlessness Simulation; interstitial fluid; interstitial system; tracer-based magnetic resonance imaging; brain extracellular space; hindlimb-unloading; simulated microgravity

The smooth transportation of substances through the brain extracellular space (ECS) is crucial to maintaining brain function; however, the way this occurs under simulated microgravity remains unclear. In this study, tracer-based magnetic resonance imaging (MRI) and D ECS -mapping techniques were use...