Cytomegalovirus Infection in Pediatric Solid Organ Transplant Recipients: a Focus on Prevention

Solid organ transplantation is a life-saving procedure that has changed the prognosis for infants and children with end-stage organ disease. Cytomegalovirus (CMV) is one of the most common infections that occur after organ transplantation in pediatric patients, yet the standard of care for CMV preve...

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Bibliographic Details
Published inCurrent infectious disease reports Vol. 18; no. 2; p. 5
Main Authors Tsai, Karen C., Danziger-Isakov, Lara A., Banach, David B.
Format Journal Article
LanguageEnglish
Published New York Springer US 2016
Springer Nature B.V
Subjects
Infections
Infectious Diseases
Medicine
Medicine & Public Health
N Theodoropoulos and S Pegram
Pediatrics
Prevention
Prophylaxis
Risk factors
Section Editors
Topical Collection on Transplant and Oncology
Transplant and Oncology (M Ison
Transplantation
Transplants & implants
Viruses
Preemptive
Cytomegalovirus
Prophylaxis
Hybrid
Solid organ transplantation
CMV
Pediatric
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Summary:Solid organ transplantation is a life-saving procedure that has changed the prognosis for infants and children with end-stage organ disease. Cytomegalovirus (CMV) is one of the most common infections that occur after organ transplantation in pediatric patients, yet the standard of care for CMV prevention remains unclear. We review the literature regarding CMV disease effects, risk factors, diagnostics, prevention strategies, and antiviral treatment in pediatric solid organ transplantation. This discussion focuses on the current prevention strategies: prophylaxis, preemptive, and hybrid therapy, as well as novel strategies that may help better prevent the CMV disease in the pediatric solid organ transplant population.
Bibliography:ObjectType-Article-1
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ISSN:1523-3847
1534-3146
DOI:10.1007/s11908-015-0511-8