Hypochlorite-Induced Oxidative Modification of Fibrinogen

• Published in: Doklady. Biochemistry and biophysics Vol. 484; no. 1; pp. 37 - 41
• Main Authors: Yurina, L. V., Vasilyeva, A. D., Bugrova, A. E., Indeykina, M. I., Kononikhin, A. S., Nikolaev, E. N., Rosenfeld, M. A.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.05.2019; Springer Nature B.V
• Subjects: Amino acids; Biochemistry; Biological and Medical Physics; Biomedical and Life Sciences; Biophysics; Fibrin; Fibrinogen; Life Sciences; Mass spectroscopy; Molecular Biology; Oxidation; Self-assembly

Oxidation of fibrinogen with hypochlorite inhibited the fibrin network self-assembly even at the lowest concentration of the oxidant. The analysis of the results of protein electrophoresis at this hypochlorite concentration showed the absence of fragmentation of the protein and covalent cross-linkin...