A scalable approach to diaminopyrazoles using flow chemistry

This Letter reports on how the combination of microwave and continuous flow chemistry facilitated the convenient preparation of aminopyrazoles from commercial aryl halides. The method was applied to a variety of substrates with good to excellent yields and further extended toward the complete flow s...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 34; pp. 4498 - 4501
Main Authors Wilson, Noel S., Osuma, Augustine T., Camp, Jennifer A.Van, Xu, Xiangdong
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 22.08.2012
Elsevier
Subjects
Aminopyrazole
Chemistry
Chemistry, Organic
Flow chemistry
Physical Sciences
Pyrazolopyrimidine
Science & Technology
Sequential flow process
Single mode microwave
Aminopyrazole
Pyrazolopyrimidine
Single mode microwave
Flow chemistry
Sequential flow process
SCALE-UP
REACTOR
MICROWAVE
BATCH
SAFE
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Summary:This Letter reports on how the combination of microwave and continuous flow chemistry facilitated the convenient preparation of aminopyrazoles from commercial aryl halides. The method was applied to a variety of substrates with good to excellent yields and further extended toward the complete flow synthesis of 5,7-dimethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-amine.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.05.152