Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

• Published in: Nature microbiology Vol. 5; no. 1; pp. 27 - 33
• Main Authors: Imai, Masaki, Yamashita, Makoto, Sakai-Tagawa, Yuko, Iwatsuki-Horimoto, Kiyoko, Kiso, Maki, Murakami, Jurika, Yasuhara, Atsuhiro, Takada, Kosuke, Ito, Mutsumi, Nakajima, Noriko, Takahashi, Kenta, Lopes, Tiago J. S., Dutta, Jayeeta, Khan, Zenab, Kriti, Divya, van Bakel, Harm, Tokita, Akifumi, Hagiwara, Haruhisa, Izumida, Naomi, Kuroki, Haruo, Nishino, Tamon, Wada, Noriyuki, Koga, Michiko, Adachi, Eisuke, Jubishi, Daisuke, Hasegawa, Hideki, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2020; Nature Publishing Group
• Subjects: 45/23; 631/326; 631/326/22; 631/326/596/1578; 692/420; Animals; Antiviral Agents - pharmacology; Biomedical and Life Sciences; Brief Communication; Cricetinae; Dibenzothiepins; Drug Resistance, Viral; Ferrets; Humans; Infectious Diseases; Influenza; Influenza A; Influenza A virus - drug effects; Influenza A virus - isolation & purification; Influenza A virus - pathogenicity; Influenza A virus - physiology; Influenza, Human - transmission; Influenza, Human - virology; Japan; Life Sciences; Medical Microbiology; Mice; Microbiology; Morpholines; Mutation; Nasal Lavage Fluid - virology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Oxazines - pharmacology; Pandemics; Parasitology; Pathogenicity; Pyridines - pharmacology; Pyridones; RNA-Dependent RNA Polymerase - genetics; Thiepins - pharmacology; Triazines - pharmacology; Viral Proteins - genetics; Virology; Virulence; Virus Replication; Japan

Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and after treatment with baloxavir marboxil in Japan....