Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets - Imai, Masaki; Yamashita, Makoto; Sakai-Tagawa, Yuko; Iwatsuki-Horimoto, Kiyoko; Kiso, Maki; Murakami, Jurika; Yasuhara, Atsuhiro; Takada, Kosuke; Ito, Mutsumi; Nakajima, Noriko; Takahashi, Kenta; Lopes, Tiago J. S.; et al. (Nature microbiology, 2020)
Keywords: 45/23; 631/326; 631/326/22; 631/326/596/1578; 692/420; Animals; Antiviral Agents - pharmacology; Biomedical and Life Sciences; Brief Communication; Cricetinae; Dibenzothiepins; Drug Resistance, Viral; Ferrets; Humans; Infectious Diseases; Influenza; Influenza A; Influenza A virus - drug effects; Influenza A virus - isolation & purification; Influenza A virus - pathogenicity; Influenza A virus - physiology; Influenza, Human - transmission; Influenza, Human - virology; Japan; Life Sciences; Medical Microbiology; Mice; Microbiology; Morpholines; Mutation; Nasal Lavage Fluid - virology; Orthomyxoviridae Infections - transmission; Orthomyxoviridae Infections - virology; Oxazines - pharmacology; Pandemics; Parasitology; Pathogenicity; Pyridines - pharmacology; Pyridones; RNA-Dependent RNA Polymerase - genetics; Thiepins - pharmacology; Triazines - pharmacology; Viral Proteins - genetics; Virology; Virulence; Virus Replication; Japan