Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation

• Published in: The Journal of immunology (1950) Vol. 188; no. 3; pp. 1431 - 1441
• Main Authors: Hardy, Charles L, LeMasurier, Jeanne S, Belz, Gabrielle T, Scalzo-Inguanti, Karen, Yao, Jun, Xiang, Sue D, Kanellakis, Peter, Bobik, Alex, Strickland, Deborah H, Rolland, Jennifer M, O'Hehir, Robyn E, Plebanski, Magdalena
• Format: Journal Article
• Language: English
• Published: United States 01.02.2012
• Subjects: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Dendritic Cells - drug effects; Dendritic Cells - immunology; Lung - immunology; Mice; Nanostructures - therapeutic use; Oxidative Stress; Pneumonia - drug therapy; Pneumonia - prevention & control; Polystyrenes - therapeutic use

Nanoparticles are being developed for diverse biomedical applications, but there is concern about their potential to promote inflammation, particularly in the lung. Although a variety of ambient, anthropogenic and man-made nanoparticles can promote lung inflammation, little is known about the long-t...