Long-term body composition and metabolic changes in HIV-infected children switched from stavudine to tenofovir and from protease inhibitors to efavirenz

• Published in: European journal of pediatrics Vol. 172; no. 8; pp. 1089 - 1096
• Main Authors: Fabiano, Valentina, Giacomet, Vania, Viganò, Alessandra, Bedogni, Giorgio, Stucchi, Sara, Cococcioni, Lucia, Mora, Stefano, Zuccotti, Gian Vincenzo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2013; Springer Nature B.V
• Subjects: Absorptiometry, Photon; Adenine - administration & dosage; Adenine - analogs & derivatives; Adolescent; Anti-Retroviral Agents - administration & dosage; Benzoxazines - administration & dosage; Blood Glucose - analysis; Body composition; Body Composition - drug effects; Body fat; Body mass index; Child; Child, Preschool; Cholesterol; Cohort analysis; Cohort Studies; Cross-sectional studies; Female; Glucose; High density lipoprotein; HIV; HIV Infections - drug therapy; HIV Infections - metabolism; Human immunodeficiency virus; Humans; Immunology; Lamivudine - administration & dosage; Linear Models; Lipids - blood; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Metabolism; Organophosphonates - administration & dosage; Original Article; Pediatrics; Scanners; Stavudine - administration & dosage; Tenofovir; Triglycerides; United Kingdom > UK; United States > US; Italy; Metabolic parameters; Children; HIV infection; Body composition
• DOI: 10.1007/s00431-013-2018-3
• ISSN: 0340-6199

This is an 8-year cohort study of 24 HIV-infected patients aged 5–17 years to assess body composition and metabolic changes after switching from lamivudine + stavudine (d4T) + protease inhibitors (PI) to lamivudine + tenofovir (TDF) + efavirenz (EFV). Body composition (dual-energy X-ray absorptiometry) and cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, glucose and insulin were measured annually. Linear mixed models and generalized linear mixed models were used to evaluate time changes of the outcome of interest. Body mass index increased linearly by 0.3 kg/m 2 /year ( p  < 0.001); waist circumference increased non-linearly from 68 to 74 cm ( p  = 0.004 for the linear term and p  = 0.04 for the quadratic term). Percent body fat, percent trunk fat and percent bone mineral content increased linearly by 0.6 %/year ( p  = 0.005), 1.2 %/year ( p  < 0.001) and 0.02 %/year ( p  = 0.04), respectively. Percent arm fat remained stable ( p  = 0.5), and percent leg fat decreased linearly by 1.2 %/year ( p  < 0.001). The probability of low HDL was 0.2 % at baseline and remained stable during the study. The probability of high triglycerides was 3 % at baseline and increased linearly to become 11 % at the 8th year of follow-up ( p  = ns). The probability of high glucose was 1 % for the whole study duration. Conclusions : patients, after switching from d4T to TDF and from PI to EFV, show most of the changes in anthropometry and body composition associated with normal growth and no frankly pathological change in metabolic parameters.