POEMS syndrome--a case for more aggressive treatment

Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical manifestations and are often seen by a variety of specialists prior to diagnosis. We describe a case of POEMS syndrome that first presented with sign...

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Published inAnnals of the Academy of Medicine, Singapore Vol. 36; no. 6; pp. 435 - 437
Main Authors Rathakrishnan, Rahul, Liu, Te-Chih, Chan, Yee-Cheun, Ong, Benjamin K C
Format Journal Article
LanguageEnglish
Published Singapore 01.06.2007
Subjects
Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - physiopathology
Humans
Immunologic Factors - therapeutic use
Male
Middle Aged
POEMS Syndrome - complications
POEMS Syndrome - drug therapy
POEMS Syndrome - radiotherapy
Treatment Outcome
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Abstract Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical manifestations and are often seen by a variety of specialists prior to diagnosis. We describe a case of POEMS syndrome that first presented with significant neuropathy but progressed to develop further manifestations of the condition, including marked gastrointestinal symptoms. The patient was commenced on localised radiotherapy and chemotherapy in addition to immunomodulatory therapy for the neuropathy. We highlight several learning points that may benefit physicians from varied specialties. This case is also unique for its marked gastrointestinal manifestation. To our knowledge, this is the second reported case in the literature with this feature.
AbstractList Introduction: Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical manifestations and are often seen by a variety of specialists prior to diagnosis. Clinical Picture: We describe a case of POEMS syndrome that first presented with significant neuropathy but progressed to develop further manifestations of the condition, including marked gastrointestinal symptoms. Treatment: The patient was commenced on localised radiotherapy and chemotherapy in addition to immunomodulatory therapy for the neuropathy. 437specialties. This case is also unique for its marked gastrointestinal manifestation. To our knowledge, this is the second reported case in the literature with this feature. Key words: Demyelinating polyneuropathy, Gastrointestinal
Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical manifestations and are often seen by a variety of specialists prior to diagnosis. We describe a case of POEMS syndrome that first presented with significant neuropathy but progressed to develop further manifestations of the condition, including marked gastrointestinal symptoms. The patient was commenced on localised radiotherapy and chemotherapy in addition to immunomodulatory therapy for the neuropathy. We highlight several learning points that may benefit physicians from varied specialties. This case is also unique for its marked gastrointestinal manifestation. To our knowledge, this is the second reported case in the literature with this feature.
INTRODUCTIONPatients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical manifestations and are often seen by a variety of specialists prior to diagnosis. CLINICAL PICTUREWe describe a case of POEMS syndrome that first presented with significant neuropathy but progressed to develop further manifestations of the condition, including marked gastrointestinal symptoms. TREATMENTThe patient was commenced on localised radiotherapy and chemotherapy in addition to immunomodulatory therapy for the neuropathy. CONCLUSIONWe highlight several learning points that may benefit physicians from varied specialties. This case is also unique for its marked gastrointestinal manifestation. To our knowledge, this is the second reported case in the literature with this feature.
Author Chan, Yee-Cheun
Rathakrishnan, Rahul
Ong, Benjamin K C
Liu, Te-Chih
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Snippet Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of clinical...
Introduction: Patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of...
INTRODUCTIONPatients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal or M-protein and skin changes) syndrome exhibit a wide range of...
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StartPage 435
SubjectTerms Gastrointestinal Diseases - etiology
Gastrointestinal Diseases - physiopathology
Humans
Immunologic Factors - therapeutic use
Male
Middle Aged
POEMS Syndrome - complications
POEMS Syndrome - drug therapy
POEMS Syndrome - radiotherapy
Treatment Outcome
Title POEMS syndrome--a case for more aggressive treatment
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Volume 36
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