Action of three bioavailable antioxidants in orbital fibroblasts from patients with Graves’ orbitopathy (GO): a new frontier for GO treatment?

• Published in: Journal of endocrinological investigation Vol. 41; no. 2; pp. 193 - 201
• Main Authors: Rotondo Dottore, G., Ionni, I., Menconi, F., Casini, G., Sellari-Franceschini, S., Nardi, M., Vitti, P., Marcocci, C., Marinò, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.02.2018; Springer Nature B.V
• Subjects: Antioxidants; Antioxidants - pharmacology; Ascorbic acid; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cells, Cultured; Cysteine; Cytokines - metabolism; Cytotoxicity; Endocrinology; Female; Fibroblasts; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Glutathione; Graves Ophthalmopathy - drug therapy; Graves Ophthalmopathy - metabolism; Graves Ophthalmopathy - pathology; Humans; Hyaluronic acid; Hyaluronic Acid - metabolism; Hydrogen peroxide; Interleukin 1; Male; Medicine; Medicine & Public Health; Melatonin; Metabolic Diseases; Middle Aged; N-Acetyl-L-cysteine; Original Article; Oxidative stress; Oxidative Stress - drug effects; Patients; Reactive Oxygen Species - metabolism; Tumor necrosis factor-α; Vitamin C; γ-Interferon; Ophthalmopathy; Melatonin; Graves; Orbitopathy; Vitamin C; cysteine; Antioxidant; acetyl; Fibroblast; N-acetyl-L-cysteine

Objective Oxidative stress is involved in the pathogenesis of Graves’ orbitopathy (GO) and an antioxidant approach has been advocated for GO treatment. Here, we investigated the action of three antioxidants in orbital fibroblasts, namely, vitamin C, N -acetyl- l -cysteine, and melatonin. Methods Pri...