Clinical features and prognosis of multiple myeloma and orbital extramedullary disease: Seven cases report and review of literature

Multiple myeloma (MM) complicated with extramedullary disease (EMD) has a poor prognosis and is a limiting factor in the treatment of MM, and no standard treatment is recommended in international guidelines. Few studies have reported MM with periorbital EMD. In this paper, the clinical characteristi...

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Bibliographic Details
Published inWorld journal of clinical cases Vol. 10; no. 33; pp. 12365 - 12374
Main Authors Hu, Wan-Li, Song, Jia-Yin, Li, Xin, Pei, Xiao-Jiao, Zhang, Jia-Jia, Shen, Man, Tang, Ran, Pan, Zhen-Yu, Huang, Zhong-Xia
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 26.11.2022
Subjects
Case Report
Periorbital
Case report
Treatment
Extramedullary disease
Survival
Multiple myeloma
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Summary:Multiple myeloma (MM) complicated with extramedullary disease (EMD) has a poor prognosis and is a limiting factor in the treatment of MM, and no standard treatment is recommended in international guidelines. Few studies have reported MM with periorbital EMD. In this paper, the clinical characteristics and survival of seven patients with multiple myeloma and orbital are described and analyzed. The common ocular symptoms were blurred vision, proptosis and/or eye movement disorders, IgG type MM may be a risk factor for orbital involvement. Of them, six patients were treated with bortezomib-based regimens. The median overall survival (OS) and progression free survival for the entire cohort were 48 and 33 mo, respectively, which was much worse than the OS reported for MM patients without orbital EMD Orbital MM may have significantly shortened survival for the entire cohort, so multidisciplinary collaboration is emphasized and recommended in the diagnosis and treatment of these difficult cases.
Bibliography:Supported by Science and Technology Project of Beijing Science and Technology Commission, No. Z171100000417010; Construction Project on Key Medical Disciplines of Shijingshan District Health Committee of Beijing Municipality.
Author contributions: Huang ZX was designed, conducted and manuscript writing; The data were collected primarily by Hu WL and Song JY, assisted by Li X, Pei XJ, Zhang JJ, Shen M, Tang R and Pan ZY; Statistical analysis and manuscript writing were partly completed by Hu WL and Song JY; All authors agreed to publish the final manuscript in this journal. Hu WL and Song JY contributed equally to this article.
Corresponding author: Zhong-Xia Huang, MD, Chief Physician, Director, Professor, Department of Hematology, Multiple Myeloma Medical Center of Beijing, Beijing Chao-Yang Hospital, Capital Medical University, No. 5 Jingyuan Road, Shijingshan District, Beijing 100043, China. huangzhongxia@sina.com
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v10.i33.12365