The NLRP3 Inflammasome: An Important Driver of Neuroinflammation in Hemorrhagic Stroke

Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important element that involves both acute brain injury and subsequent brain rehabilitation. Therefore, delineating the key inflammatory mediators and...

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Published in	Cellular and molecular neurobiology Vol. 38; no. 3; pp. 595 - 603
Main Authors	Yang, Shao-Jun, Shao, Gao-Feng, Chen, Jiang-Li, Gong, Jie
Format	Journal Article
Language	English
Published	New York Springer US 01.04.2018 Springer Nature B.V
Subjects	Biomedical and Life Sciences Biomedicine Brain injury Caspase Caspase-1 Cell activation Cell Biology Cellular stress response Cytoplasm Hemorrhage Immune response Inflammasomes Inflammation Innate immunity Interleukin 18 Neurobiology Neurosciences Pyrin protein Rehabilitation Review Paper Stroke Therapeutic applications NLRP3 Neuroinflammation Inflammasome Hemorrhagic stroke Brain injury
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Abstract	Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important element that involves both acute brain injury and subsequent brain rehabilitation. Therefore, delineating the key inflammatory mediators and deciphering their pathophysiological roles in hemorrhagic strokes is of great importance in the development of novel therapeutic targets for this disease. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that is localized within the cytoplasm. This NOD-like receptor orchestrates innate immune responses to pathogenic organisms and cell stress through the activation of caspase-1 and the maturation of the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Mounting evidence has demonstrated that when the NLRP3 inflammasome is activated, it exerts harmful effects on brain tissue after a hemorrhagic stroke. This review article summarizes the current knowledge regarding the role and the underlying mechanisms of the NLRP3 inflammasome in the pathophysiological processes of hemorrhagic strokes. A better understanding of the function and regulation of the NLRP3 inflammasome in hemorrhagic strokes will provide clues for devising novel therapeutic strategies to fight this disease.
AbstractList	Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important element that involves both acute brain injury and subsequent brain rehabilitation. Therefore, delineating the key inflammatory mediators and deciphering their pathophysiological roles in hemorrhagic strokes is of great importance in the development of novel therapeutic targets for this disease. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that is localized within the cytoplasm. This NOD-like receptor orchestrates innate immune responses to pathogenic organisms and cell stress through the activation of caspase-1 and the maturation of the proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18. Mounting evidence has demonstrated that when the NLRP3 inflammasome is activated, it exerts harmful effects on brain tissue after a hemorrhagic stroke. This review article summarizes the current knowledge regarding the role and the underlying mechanisms of the NLRP3 inflammasome in the pathophysiological processes of hemorrhagic strokes. A better understanding of the function and regulation of the NLRP3 inflammasome in hemorrhagic strokes will provide clues for devising novel therapeutic strategies to fight this disease.
Author	Gong, Jie Shao, Gao-Feng Yang, Shao-Jun Chen, Jiang-Li
Author_xml	– sequence: 1 givenname: Shao-Jun surname: Yang fullname: Yang, Shao-Jun organization: Department of Neurosurgery, Zhuji People’s Hospital of Zhejiang Province – sequence: 2 givenname: Gao-Feng surname: Shao fullname: Shao, Gao-Feng organization: Department of Neurosurgery, Zhuji People’s Hospital of Zhejiang Province – sequence: 3 givenname: Jiang-Li surname: Chen fullname: Chen, Jiang-Li organization: Department of Neurosurgery, Zhuji People’s Hospital of Zhejiang Province – sequence: 4 givenname: Jie surname: Gong fullname: Gong, Jie email: gongjieneuro@hotmail.com, orchidwave@163.com organization: Department of Neurosurgery, Zhejiang Hospital of Zhejiang Province
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Keywords	NLRP3 Neuroinflammation Inflammasome Hemorrhagic stroke Brain injury
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Snippet	Hemorrhagic stroke is a devastating clinical event with no effective medical treatment. Neuroinflammation, which follows a hemorrhagic stroke, is an important...
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SubjectTerms	Biomedical and Life Sciences Biomedicine Brain injury Caspase Caspase-1 Cell activation Cell Biology Cellular stress response Cytoplasm Hemorrhage Immune response Inflammasomes Inflammation Innate immunity Interleukin 18 Neurobiology Neurosciences Pyrin protein Rehabilitation Review Paper Stroke Therapeutic applications
Title	The NLRP3 Inflammasome: An Important Driver of Neuroinflammation in Hemorrhagic Stroke
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