Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome
Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8 + T, γδ T and CD4 + T cells; these data suggest tha...
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| Published in | Neurological sciences Vol. 37; no. 5; pp. 793 - 795 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Milan
Springer Milan
01.05.2016
Springer Nature B.V |
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| Abstract | Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8
+
T, γδ T and CD4
+
T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems. |
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| AbstractList | Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein-Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8^sup +^ T, γδ T and CD4^sup +^ T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein-Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems. Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein-Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8(+) T, γδ T and CD4(+) T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein-Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems. Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein-Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8(+) T, γδ T and CD4(+) T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein-Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems.Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein-Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8(+) T, γδ T and CD4(+) T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein-Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems. Down syndrome is characterized by dysmorphic features, mental retardation and problems of immune deficiency. Chronic infection by Epstein–Barr virus is frequently present in subjects with Down syndrome. Ksp37 gene is commonly expressed by NK, CD8 + T, γδ T and CD4 + T cells; these data suggest that Ksp37 have cytotoxic properties. An increase of Ksp37 protein serum levels it has been showed during the acute phase of Epstein–Barr virus. In this study, we evaluated the expression of Ksp37 mRNA, in fibroblasts and leukocytes of DS subjects and in normal subjects with realtime reverse transcription-PCR. This analysis shows that in fibroblasts and leukocytes of Down syndrome subjects the KSP37 gene expression was increased compared with control subjects. The results of this study suggest that the expression of Ksp37 gene might be associated with increased susceptibility of individuals with Down syndrome to EBV infections and autoimmune problems. |
| Author | Rando, Rosanna G. Galati Ragalmuto, Alda Salluzzo, Maria Grazia Romano, Corrado Caniglia, Salvatore Salemi, Michele Bosco, Paolo Romano, Carmelo Barone, Concetta Morale, Maria Concetta |
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| References | Hayano, Koi, Ogawa (CR6) 2002; 48 Romagnani (CR9) 2001; 1 de Hingh, van der Vossen, Gemen (CR2) 2005; 147 Ogawa, Tanaka, Ishii (CR5) 2001; 166 Kuepper, Koester, Bratke (CR7) 2004; 137 Salemi, Barone, Romano (CR8) 2013; 34 Mrak, Griffin (CR1) 2004; 63 Kuitert, Abbink, Broers (CR4) 2014; 158 Bull (CR3) 2011; 128 M Salemi (2554_CR8) 2013; 34 RE Mrak (2554_CR1) 2004; 63 K Ogawa (2554_CR5) 2001; 166 C Hayano (2554_CR6) 2002; 48 MJ Bull (2554_CR3) 2011; 128 YC Hingh de (2554_CR2) 2005; 147 M Kuepper (2554_CR7) 2004; 137 S Romagnani (2554_CR9) 2001; 1 PC Kuitert (2554_CR4) 2014; 158 |
| References_xml | – volume: 34 start-page: 2023 year: 2013 end-page: 2025 ident: CR8 article-title: Pericentrin expression in Down’s syndrome publication-title: Neurol Sci doi: 10.1007/s10072-013-1529-z – volume: 63 start-page: 679 year: 2004 end-page: 685 ident: CR1 article-title: Trisomy 21 and the brain publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/63.7.679 – volume: 128 start-page: 393 year: 2011 end-page: 406 ident: CR3 article-title: Committee on Genetics. Health supervision for children with Down syndrome publication-title: Pediatrics doi: 10.1542/peds.2011-1605 – volume: 158 start-page: A7608 year: 2014 ident: CR4 article-title: Epstein–Barr virus infection with severe consequences. EBV, haemophagocytic lymphohistiocytosis and Hodgkin lymphoma with Down syndrome publication-title: Ned Tijdschr Geneeskd – volume: 147 start-page: 744 year: 2005 end-page: 747 ident: CR2 article-title: Intrinsic abnormalities of lymphocyte counts in children with down syndrome publication-title: J Pediatr doi: 10.1016/j.jpeds.2005.07.022 – volume: 166 start-page: 6404 year: 2001 end-page: 6412 ident: CR5 article-title: A novel serum protein that is selectively produced by cytotoxic lymphocytes publication-title: J Immun doi: 10.4049/jimmunol.166.10.6404 – volume: 48 start-page: 57 year: 2002 end-page: 62 ident: CR6 article-title: Accumulation of CD16 cells with secretion of Ksp37 in decidua at the end of pregnancy publication-title: Am J Reprod Immun doi: 10.1034/j.1600-0897.2002.01100.x – volume: 137 start-page: 359 year: 2004 end-page: 365 ident: CR7 article-title: Increase in Ksp37-positive peripheral blood lymphocytes in mild extrinsic asthma publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2004.02540.x – volume: 1 start-page: 73 year: 2001 end-page: 78 ident: CR9 article-title: T-cell responses in allergy and asthma publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/01.all.0000010988.60715.c8 – volume: 147 start-page: 744 year: 2005 ident: 2554_CR2 publication-title: J Pediatr doi: 10.1016/j.jpeds.2005.07.022 – volume: 128 start-page: 393 year: 2011 ident: 2554_CR3 publication-title: Pediatrics doi: 10.1542/peds.2011-1605 – volume: 1 start-page: 73 year: 2001 ident: 2554_CR9 publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/01.all.0000010988.60715.c8 – volume: 158 start-page: A7608 year: 2014 ident: 2554_CR4 publication-title: Ned Tijdschr Geneeskd – volume: 63 start-page: 679 year: 2004 ident: 2554_CR1 publication-title: J Neuropathol Exp Neurol doi: 10.1093/jnen/63.7.679 – volume: 166 start-page: 6404 year: 2001 ident: 2554_CR5 publication-title: J Immun doi: 10.4049/jimmunol.166.10.6404 – volume: 48 start-page: 57 year: 2002 ident: 2554_CR6 publication-title: Am J Reprod Immun doi: 10.1034/j.1600-0897.2002.01100.x – volume: 137 start-page: 359 year: 2004 ident: 2554_CR7 publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2004.02540.x – volume: 34 start-page: 2023 year: 2013 ident: 2554_CR8 publication-title: Neurol Sci doi: 10.1007/s10072-013-1529-z |
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| Title | Killer-specific secretory (Ksp37) gene expression in subjects with Down’s syndrome |
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