Genetics of Drug Response in Type 2 Diabetes
The introduction of several new drug groups into the treatment of type 2 diabetes in the past few decades leads to an increased requirement for an individualized treatment approach. A personalized treatment is important from the point of view of both efficacy and safety. Recent guidelines are based...
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| Published in | Current diabetes reports Vol. 15; no. 7; p. 43 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.07.2015
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1534-4827 1539-0829 |
| DOI | 10.1007/s11892-015-0617-2 |
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| Abstract | The introduction of several new drug groups into the treatment of type 2 diabetes in the past few decades leads to an increased requirement for an individualized treatment approach. A personalized treatment is important from the point of view of both efficacy and safety. Recent guidelines are based mainly on entirely phenotypic characteristics such as diabetes duration, presence of macrovascular complications, or risk of hypoglycemia with the use of individual drugs. So far, genetic knowledge is used to guide treatment in the monogenic forms of diabetes. With the accumulating pharmacogenetic evidence in type 2 diabetes, there are reasonable expectations that genetics might help in the adjustment of drug doses to reduce severe side effects, as well as to make better therapeutic choices among the drugs available for the treatment of diabetes. |
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| AbstractList | The introduction of several new drug groups into the treatment of type 2 diabetes in the past few decades leads to an increased requirement for an individualized treatment approach. A personalized treatment is important from the point of view of both efficacy and safety. Recent guidelines are based mainly on entirely phenotypic characteristics such as diabetes duration, presence of macrovascular complications, or risk of hypoglycemia with the use of individual drugs. So far, genetic knowledge is used to guide treatment in the monogenic forms of diabetes. With the accumulating pharmacogenetic evidence in type 2 diabetes, there are reasonable expectations that genetics might help in the adjustment of drug doses to reduce severe side effects, as well as to make better therapeutic choices among the drugs available for the treatment of diabetes. |
| ArticleNumber | 43 |
| Author | Tkáč, Ivan |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25975599$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3389_fphar_2018_00320 crossref_primary_10_1016_j_ebiom_2016_10_025 crossref_primary_10_3389_fnut_2023_1135759 crossref_primary_10_1016_j_genrep_2020_100787 crossref_primary_10_1080_17446651_2017_1323631 crossref_primary_10_2217_pme_2016_0022 |
| Cites_doi | 10.1097/FPC.0b013e32834c0010 10.1016/j.clpt.2005.04.013 10.1172/JCI13505 10.1056/NEJM197805252982103 10.1038/tpj.2009.15 10.2337/dc11-2301 10.1111/j.1463-1326.2012.01691.x 10.2337/db08-1589 10.2337/db11-1732 10.1210/jc.2005-2323 10.2337/db13-0227 10.2337/db08-0896 10.1016/S0140-6736(98)07037-8 10.2337/diacare.28.5.1139 10.1056/NEJMoa062418 10.1007/s11010-007-9575-6 10.1006/bbrc.1997.7798 10.1210/jc.2006-2275 10.1007/s00228-011-1013-8 10.1007/s10038-006-0087-0 10.2337/db08-1028 10.1074/jbc.M411487200 10.1111/j.1463-1326.2012.01675.x 10.2165/11534750-000000000-00000 10.1111/ijcp.12534 10.1111/j.1399-5448.2009.00571.x 10.1016/j.cmet.2014.08.005 10.1007/s00125-009-1344-5 10.1056/NEJMoa061759 10.1038/clpt.2014.109 10.2337/db06-0381 10.2337/db10-0543 10.1007/s00125-007-0753-6 10.1155/2013/374858 10.2337/dc09-1727 10.4161/cc.10.9.15423 10.1177/193229680900300415 10.2337/db09-1169 10.2337/db07-0381 10.1172/JCI40671 10.1085/jgp.110.6.655 10.1016/j.abb.2012.04.020 10.1016/j.clpt.2005.03.008 10.1067/mcp.2002.122476 10.1016/S0140-6736(03)14571-0 10.1046/j.1464-5491.2001.00449.x 10.1038/aps.2012.144 10.1016/S2213-8587(14)70050-6 10.1038/ng.735 10.2337/db09-0143 10.1016/j.diabres.2006.10.021 10.1038/clpt.2009.176 10.1186/1471-2350-10-15 10.1038/clpt.2011.165 10.1016/S0140-6736(06)69705-5 10.1038/clpt.2012.210 10.1007/s00125-012-2534-0 10.1172/JCI30558 10.2217/pgs.14.17 10.1073/pnas.0730870100 10.2337/db07-0440 10.1038/ng.521 10.2217/14622416.9.4.415 10.1038/nature11808 10.2337/diabetes.53.5.1360 10.1093/aje/kwp450 10.1007/s00125-012-2537-x 10.1007/s11033-011-1354-5 10.2337/dc07-1785 10.1016/j.ejim.2011.10.018 10.1038/ng1732 10.1056/NEJMoa066224 10.1038/nature13270 10.2337/diacare.26.3.825 10.1016/j.metabol.2009.10.030 10.1111/j.1745-7254.2008.00840.x 10.2337/dc07-2248 10.1038/sj.clpt.6100275 10.1111/j.1463-1326.2007.00832.x 10.1007/s00125-014-3276-y 10.2337/dc10-0200 10.1001/archinternmed.2009.20 10.1038/clpt.2009.92 10.1111/j.1463-1326.2008.00905.x |
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| Keywords | Type 2 diabetes Incretins Pharmacogenetics Glitazones Metformin Sulfonylurea |
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| References | Becker, Visser, van Schaik (CR33) 2009; 9 Saxena, Hivert, Langenberg (CR74) 2010; 42 Stocker, Morrissey, Yee (CR29) 2013; 93 Javorsky, Klimcakova, Schroner (CR46) 2012; 23 Kahn, Haffner, Heise (CR85) 2006; 355 Gouda, Sagoo, Harding (CR63) 2010; 171 Saxena, Gianniny, Burt (CR51) 2006; 55 Zimdahl, Ittrich, Graefe-Mody (CR80) 2014; 57 Kang, Park, Kim (CR65) 2005; 78 Pearson, Starkey, Powell (CR83) 2003; 362 Zhou, Myers, Li (CR8) 2001; 108 Smith, Covington, Schnellmann (CR15) 2012; 523 Florez, Burtt, de Bakker (CR40) 2004; 53 Hsieh, Lin, Tien (CR64) 2010; 59 Pei, Huang, Yang (CR66) 2013; 34 Zhou, Guo, Ye (CR18) 2014; 68 Zhou, Donnelly, Burch (CR59) 2010; 87 Florez, Jablonski, Taylor (CR19) 2012; 35 Becker, Pearson, Tkáč (CR2) 2013; 2013 Takane, Shikata, Otsubo (CR26) 2008; 9 Florez, Jablonski, Sun (CR67) 2007; 92 He, Zhang, Shao (CR47) 2008; 29 Miller, Chu, Xie (CR13) 2013; 494 Schäfer, Müssig, Staiger (CR78) 2009; 52 Shu, Sheardown, Brown (CR24) 2007; 117 Smushkin, Sathananthan, Sathananthan (CR79) 2012; 61 Tong, Lin, Zhang (CR49) 2009; 10 Christensen, Brasch-Andersen, Green (CR34) 2011; 21 Sathamanthan, Dalla, Micheletto (CR73) 2010; 33 Grant, Thorleifsson, Reinisdottir (CR48) 2006; 38 Hamming, Soliman, Matemisz (CR41) 2009; 58 Kang, Park, Kim (CR69) 2005; 28 Rhee, Inoue, Yoon (CR9) 2003; 100 Shikata, Yamamoto, Takane (CR28) 2007; 52 Sherifali, Nerenberg, Pulenayegum (CR5) 2010; 33 Jablonski, McAteer, Bakker (CR14) 2010; 59 Zhou, Donnelly, Kimber (CR35) 2009; 58 Soccio, Chen, Lazar (CR61) 2014; 20 Müssig, Staiger, Machicao (CR77) 2009; 57 Hattersley, Bruining, Shield (CR84) 2009; 10 Zhou, Bellenguez, Spencer (CR16) 2011; 43 Feng, Mao, Ren (CR44) 2008; 31 Shyng, Nichols (CR37) 1997; 110 Pearson, Donelly, Kimber (CR54) 2007; 56 Kim, Park, Lee (CR10) 2008; 57 Tzvetkov, Vormfelde, Balen (CR27) 2009; 86 Gloyn, Hashim, Ashcroft (CR42) 2001; 18 Florez, Jablonski, Bayley (CR53) 2006; 355 Rossi, Cammarata, Dharmavaram, Weck (CR82) 2014; 15 Bluher, Lubben, Paschke (CR68) 2003; 26 Kooy, de Jager, Lehert (CR7) 2009; 169 Villareal, Robertson, Bell (CR52) 2010; 59 Goswami, Yee, Stocker (CR36) 2014; 96 Wang, Chen, Wen (CR58) 2005; 78 Zhou, Donnelly, Yang (CR4) 2014; 2 Javorský, Babjaková, Klimčáková (CR55) 2013; 2013 Namvaran, Rahimi-Moghaddam, Azarpira (CR71) 2012; 39 Rafiq, Flanagan, Patch (CR39) 2008; 31 Choi, Yee, Ramirez (CR32) 2011; 90 Sesti, Laratta, Cardellini (CR43) 2006; 91 Li, Peng, Wu (CR70) 2008; 10 Sun, Connors, Yang (CR22) 2007; 306 Surendiran, Pradhan, Agrawal (CR60) 2011; 67 (CR6) 1998; 352 Tkáč, Klimčáková, Javorský (CR31) 2013; 15 Færch, Pilgaard, Knop (CR76) 2013; 15 Kirchheiner, Brockmoller, Meineke (CR57) 2002; 71 Becker, Visser, van Schaik (CR30) 2009; 58 Drucker, Nauck (CR72) 2006; 368 Vella (CR3) 2009; 3 Madiraju, Erion, Rahimi (CR12) 2014; 510 van Leeuwen, Nijpels, Becker (CR17) 2012; 55 Schäfer, Tschritter, Machicao (CR75) 2007; 50 Vazquez-Martin, Oliveras-Ferraros, Cifí (CR21) 2011; 10 Shu, Brown, Castro (CR25) 2008; 83 Holstein, Hahnl, Körner (CR56) 2011; 24 Yen, Beamer, Negri (CR62) 1997; 241 Pearson, Flechtner, Njolstad (CR38) 2006; 355 Inzucchi, Bergenstal, Buse (CR1) 2012; 55 Foretz, Hébrard, Leclerc (CR11) 2010; 120 Bar, Lewis, Rechler (CR20) 1978; 298 t Haart, Fritsche, Nijpels (CR81) 2013; 62 Zhang, Liu, Kuang (CR45) 2007; 77 Yi, Brubaker, Jin (CR50) 2005; 280 Graham, Punt, Arora (CR23) 2011; 50 AL Gloyn (617_CR42) 2001; 18 A Vella (617_CR3) 2009; 3 LM ‘t Haart (617_CR81) 2013; 62 K Zhou (617_CR59) 2010; 87 DJ Drucker (617_CR72) 2006; 368 AK Madiraju (617_CR12) 2014; 510 MA Smith (617_CR15) 2012; 523 M Javorský (617_CR55) 2013; 2013 H Zhang (617_CR45) 2007; 77 MM Christensen (617_CR34) 2011; 21 GG Graham (617_CR23) 2011; 50 ER Pearson (617_CR54) 2007; 56 ES Kang (617_CR69) 2005; 28 UK Prospective Diabetes Study (UKPDS) Group (617_CR6) 1998; 352 KA Jablonski (617_CR14) 2010; 59 JH Choi (617_CR32) 2011; 90 ML Becker (617_CR2) 2013; 2013 JC Florez (617_CR67) 2007; 92 MV Tzvetkov (617_CR27) 2009; 86 R Wang (617_CR58) 2005; 78 RS Bar (617_CR20) 1978; 298 H Takane (617_CR26) 2008; 9 K Zhou (617_CR35) 2009; 58 G Smushkin (617_CR79) 2012; 61 K Færch (617_CR76) 2013; 15 K Müssig (617_CR77) 2009; 57 CJ Yen (617_CR62) 1997; 241 Y Shu (617_CR25) 2008; 83 Y Feng (617_CR44) 2008; 31 ML Becker (617_CR30) 2009; 58 SA Schäfer (617_CR75) 2007; 50 SE Kahn (617_CR85) 2006; 355 SA Schäfer (617_CR78) 2009; 52 JC Florez (617_CR19) 2012; 35 M Rafiq (617_CR39) 2008; 31 F Namvaran (617_CR71) 2012; 39 S Shyng (617_CR37) 1997; 110 M Javorsky (617_CR46) 2012; 23 F Yi (617_CR50) 2005; 280 RA Miller (617_CR13) 2013; 494 Y Shu (617_CR24) 2007; 117 MC Hsieh (617_CR64) 2010; 59 S Goswami (617_CR36) 2014; 96 DT Villareal (617_CR52) 2010; 59 A Surendiran (617_CR60) 2011; 67 G Sesti (617_CR43) 2006; 91 Z Li (617_CR70) 2008; 10 R Saxena (617_CR74) 2010; 42 G Zhou (617_CR8) 2001; 108 YD Kim (617_CR10) 2008; 57 M Foretz (617_CR11) 2010; 120 I Tkáč (617_CR31) 2013; 15 ER Pearson (617_CR83) 2003; 362 N Leeuwen van (617_CR17) 2012; 55 E Shikata (617_CR28) 2007; 52 A Holstein (617_CR56) 2011; 24 I Sun (617_CR22) 2007; 306 SF Grant (617_CR48) 2006; 38 R Saxena (617_CR51) 2006; 55 ER Pearson (617_CR38) 2006; 355 JS Rossi (617_CR82) 2014; 15 KSC Hamming (617_CR41) 2009; 58 K Zhou (617_CR16) 2011; 43 Y Zhou (617_CR18) 2014; 68 JC Florez (617_CR53) 2006; 355 A Sathamanthan (617_CR73) 2010; 33 J Kirchheiner (617_CR57) 2002; 71 J Rhee (617_CR9) 2003; 100 Y Tong (617_CR49) 2009; 10 RE Soccio (617_CR61) 2014; 20 HN Gouda (617_CR63) 2010; 171 K Zhou (617_CR4) 2014; 2 D Sherifali (617_CR5) 2010; 33 ES Kang (617_CR65) 2005; 78 M Bluher (617_CR68) 2003; 26 A Hattersley (617_CR84) 2009; 10 Q Pei (617_CR66) 2013; 34 JC Florez (617_CR40) 2004; 53 A Kooy (617_CR7) 2009; 169 SL Stocker (617_CR29) 2013; 93 ML Becker (617_CR33) 2009; 9 YY He (617_CR47) 2008; 29 SE Inzucchi (617_CR1) 2012; 55 A Vazquez-Martin (617_CR21) 2011; 10 H Zimdahl (617_CR80) 2014; 57 |
| References_xml | – volume: 21 start-page: 837 year: 2011 end-page: 50 ident: CR34 article-title: The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c publication-title: Pharmacogenet Genomics doi: 10.1097/FPC.0b013e32834c0010 – volume: 78 start-page: 202 year: 2005 end-page: 8 ident: CR65 article-title: Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes publication-title: Clin Pharmacol Ther doi: 10.1016/j.clpt.2005.04.013 – volume: 108 start-page: 1167 year: 2001 end-page: 74 ident: CR8 article-title: Role of AMP-activated protein kinase in mechanism of metformin action publication-title: J Clin Invest doi: 10.1172/JCI13505 – volume: 298 start-page: 1164 year: 1978 end-page: 71 ident: CR20 article-title: Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors publication-title: N Engl J Med doi: 10.1056/NEJM197805252982103 – volume: 9 start-page: 242 year: 2009 end-page: 7 ident: CR33 article-title: Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus publication-title: Pharmacogenomics J doi: 10.1038/tpj.2009.15 – volume: 35 start-page: 1864 year: 2012 end-page: 7 ident: CR19 article-title: The C allele of ATM rs11212617 does not associate with metformin response in the diabetes prevention program publication-title: Diabetes Care doi: 10.2337/dc11-2301 – volume: 15 start-page: 189 year: 2013 end-page: 91 ident: CR31 article-title: Pharmacogenomic association between a variant in gene and therapeutic response to metformin in type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2012.01691.x – volume: 57 start-page: 1715 year: 2009 end-page: 20 ident: CR77 article-title: Association of type 2 diabetes candidate polymorphism in with incretin and insulin secretion publication-title: Diabetes doi: 10.2337/db08-1589 – volume: 61 start-page: 1082 year: 2012 end-page: 9 ident: CR79 article-title: Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1 publication-title: Diabetes doi: 10.2337/db11-1732 – volume: 91 start-page: 2334 year: 2006 end-page: 9 ident: CR43 article-title: The E23K variant of KCNJ11 encoding the pancreatic β-cell adenosine 5′-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with increased risk of secondary failure to sulphonylurea in patients with type 2 diabetes publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-2323 – volume: 62 start-page: 3275 year: 2013 end-page: 81 ident: CR81 article-title: The / locus affects diabetes susceptibility and treatment via the incretin pathway publication-title: Diabetes doi: 10.2337/db13-0227 – volume: 58 start-page: 1434 year: 2009 end-page: 9 ident: CR35 article-title: Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study publication-title: Diabetes doi: 10.2337/db08-0896 – volume: 352 start-page: 854 year: 1998 end-page: 65 ident: CR6 article-title: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) publication-title: Lancet doi: 10.1016/S0140-6736(98)07037-8 – volume: 28 start-page: 1139 year: 2005 end-page: 44 ident: CR69 article-title: The influence of adiponectin gene polymorphism on the rosiglitazone response in patients with type 2 diabetes publication-title: Diabetes Care doi: 10.2337/diacare.28.5.1139 – volume: 355 start-page: 241 year: 2006 end-page: 50 ident: CR53 article-title: TCF7L2 polymorphisms and progression to diabetes in the diabetes prevention program publication-title: N Engl J Med doi: 10.1056/NEJMoa062418 – volume: 306 start-page: 239 year: 2007 end-page: 44 ident: CR22 article-title: AICAR induces phosphorylation of AMPK in an ATM-dependent LKB1-independent manner publication-title: Mol Cell Biochem doi: 10.1007/s11010-007-9575-6 – volume: 241 start-page: 270 year: 1997 end-page: 4 ident: CR62 article-title: Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1997.7798 – volume: 92 start-page: 1502 year: 2007 end-page: 9 ident: CR67 article-title: Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-2275 – volume: 67 start-page: 797 year: 2011 end-page: 801 ident: CR60 article-title: Influence of gene polymorphismus on response to glybenclamide in type 2 diabetes mellitus patients publication-title: Eur J Clin Pharmacol doi: 10.1007/s00228-011-1013-8 – volume: 52 start-page: 117 year: 2007 end-page: 22 ident: CR28 article-title: Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin publication-title: J Hum Genet doi: 10.1007/s10038-006-0087-0 – volume: 58 start-page: 745 year: 2009 end-page: 49 ident: CR30 article-title: Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study publication-title: Diabetes doi: 10.2337/db08-1028 – volume: 280 start-page: 1457 year: 2005 end-page: 64 ident: CR50 article-title: TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinese-3β publication-title: J Biol Chem doi: 10.1074/jbc.M411487200 – volume: 15 start-page: 91 year: 2013 end-page: 5 ident: CR76 article-title: Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the rs7904146 risk T allele publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2012.01675.x – volume: 50 start-page: 81 year: 2011 end-page: 98 ident: CR23 article-title: Clinical pharmacokinetics of metformin publication-title: Clin Pharmacokinet doi: 10.2165/11534750-000000000-00000 – volume: 68 start-page: 1462 year: 2014 end-page: 6 ident: CR18 article-title: Rs11212617 is associated with metformin treatment response in type 2 diabetes in Shanghai local Chinese population publication-title: Int J Clin Pract doi: 10.1111/ijcp.12534 – volume: 10 start-page: 33 issue: Suppl 12 year: 2009 end-page: 42 ident: CR84 article-title: The diagnosis and management of monogenic diabetes in children and adolescents publication-title: Pediatr Diabetes doi: 10.1111/j.1399-5448.2009.00571.x – volume: 20 start-page: 573 year: 2014 end-page: 91 ident: CR61 article-title: Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes publication-title: Cell Metab doi: 10.1016/j.cmet.2014.08.005 – volume: 52 start-page: 1075 year: 2009 end-page: 82 ident: CR78 article-title: A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion publication-title: Diabetologia doi: 10.1007/s00125-009-1344-5 – volume: 355 start-page: 467 year: 2006 end-page: 77 ident: CR38 article-title: Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations publication-title: N Engl J Med doi: 10.1056/NEJMoa061759 – volume: 96 start-page: 370 year: 2014 end-page: 9 ident: CR36 article-title: Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2014.109 – volume: 55 start-page: 2890 year: 2006 end-page: 5 ident: CR51 article-title: Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals publication-title: Diabetes doi: 10.2337/db06-0381 – volume: 59 start-page: 2672 year: 2010 end-page: 81 ident: CR14 article-title: Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program publication-title: Diabetes doi: 10.2337/db10-0543 – volume: 50 start-page: 2443 year: 2007 end-page: 50 ident: CR75 article-title: Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 ( ) gene polymorphism publication-title: Diabetologia doi: 10.1007/s00125-007-0753-6 – volume: 2013 start-page: 374858 year: 2013 ident: CR55 article-title: Association between TCF7L2 genotype and glycemic control in diabetic patients treated with gliclazide publication-title: Int J Endocrinol doi: 10.1155/2013/374858 – volume: 33 start-page: 1859 year: 2010 end-page: 64 ident: CR5 article-title: The effect of oral antidiabetic agents on A1C levels. A systematic review and meta-analysis publication-title: Diabetes Care doi: 10.2337/dc09-1727 – volume: 10 start-page: 1499 year: 2011 end-page: 501 ident: CR21 article-title: Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response publication-title: Cell Cycle doi: 10.4161/cc.10.9.15423 – volume: 3 start-page: 705 year: 2009 end-page: 9 ident: CR3 article-title: Pharmacogenetics for type 2 diabetes. Practical considerations for study design publication-title: J Diabetes Sci Technol doi: 10.1177/193229680900300415 – volume: 59 start-page: 479 year: 2010 end-page: 85 ident: CR52 article-title: TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action publication-title: Diabetes doi: 10.2337/db09-1169 – volume: 57 start-page: 306 year: 2008 end-page: 14 ident: CR10 article-title: Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP publication-title: Diabetes doi: 10.2337/db07-0381 – volume: 120 start-page: 2355 year: 2010 end-page: 69 ident: CR11 article-title: Metformin inhibits hepatic gluconeogenesis in mice independently of the LBK1/AMPK pathway via a decrease in hepatic energy state publication-title: J Clin Invest doi: 10.1172/JCI40671 – volume: 110 start-page: 655 year: 1997 end-page: 64 ident: CR37 article-title: Octameric stoichiometry of the KATP channel complex publication-title: J Genet Physiol doi: 10.1085/jgp.110.6.655 – volume: 523 start-page: 161 year: 2012 end-page: 8 ident: CR15 article-title: Loss of calpain 10 causes mitochondrial dysfunction during chronic hyperglycemia publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2012.04.020 – volume: 78 start-page: 90 year: 2005 end-page: 2 ident: CR58 article-title: Pharmacokinetics of glimepiride and cytochrome P450 2C9 genetic polymorphisms publication-title: Clin Pharmacol Ther doi: 10.1016/j.clpt.2005.03.008 – volume: 71 start-page: 286 year: 2002 end-page: 96 ident: CR57 article-title: Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers publication-title: Clin Pharmacol Ther doi: 10.1067/mcp.2002.122476 – volume: 362 start-page: 1275 year: 2003 end-page: 81 ident: CR83 article-title: Genetic cause of hyperglycaemia and response to treatment in diabetes publication-title: Lancet doi: 10.1016/S0140-6736(03)14571-0 – volume: 18 start-page: 206 year: 2001 end-page: 12 ident: CR42 article-title: Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with type 2 diabetes mellitus (UKPDS 53) publication-title: Diabet Med doi: 10.1046/j.1464-5491.2001.00449.x – volume: 34 start-page: 225 year: 2013 end-page: 61 ident: CR66 article-title: PPAR-gamma2 and PTPRD gene polymorphisms influence type 2 diabetes patients’ response to pioglitazone in China publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2012.144 – volume: 2 start-page: 481 year: 2014 end-page: 7 ident: CR4 article-title: Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70050-6 – volume: 43 start-page: 117 year: 2011 end-page: 20 ident: CR16 article-title: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes publication-title: Nat Genet doi: 10.1038/ng.735 – volume: 58 start-page: 2419 year: 2009 end-page: 24 ident: CR41 article-title: Coexpression of the type 2 diabetes susceptibility gene variants E23K and S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K channel publication-title: Diabetes doi: 10.2337/db09-0143 – volume: 77 start-page: 58 year: 2007 end-page: 61 ident: CR45 article-title: Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2006.10.021 – volume: 87 start-page: 52 year: 2010 end-page: 56 ident: CR59 article-title: Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study publication-title: Clin Pharmacol Therap. doi: 10.1038/clpt.2009.176 – volume: 10 start-page: 15 year: 2009 ident: CR49 article-title: Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis publication-title: BMC Med Genet doi: 10.1186/1471-2350-10-15 – volume: 90 start-page: 674 year: 2011 end-page: 84 ident: CR32 article-title: A common 5′-UTR variant in MATE2-K is associated with poor response to metformin publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2011.165 – volume: 368 start-page: 1696 year: 2006 end-page: 705 ident: CR72 article-title: The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes publication-title: Lancet doi: 10.1016/S0140-6736(06)69705-5 – volume: 93 start-page: 186 year: 2013 end-page: 94 ident: CR29 article-title: The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2012.210 – volume: 55 start-page: 1577 year: 2012 end-page: 96 ident: CR1 article-title: Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) publication-title: Diabetologia doi: 10.1007/s00125-012-2534-0 – volume: 117 start-page: 1422 year: 2007 end-page: 31 ident: CR24 article-title: Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action publication-title: J Clin Invest doi: 10.1172/JCI30558 – volume: 15 start-page: 915 year: 2014 end-page: 23 ident: CR82 article-title: Clopidogrel dose adjustment after outpatient screening for variant alleles: a pilot study publication-title: Pharmacogenomics doi: 10.2217/pgs.14.17 – volume: 100 start-page: 4012 year: 2003 end-page: 17 ident: CR9 article-title: Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1α): requirement for hepatocyte nuclear factor 4α in gluconeogenesis publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.0730870100 – volume: 56 start-page: 2178 year: 2007 end-page: 82 ident: CR54 article-title: Variation in TCF7L2 influences therapeutic response to sulfonylureas, a GoDARTs study publication-title: Diabetes doi: 10.2337/db07-0440 – volume: 42 start-page: 142 year: 2010 end-page: 8 ident: CR74 article-title: Genetic variation in influences the glucose and insulin responses to an oral glucose challenge publication-title: Nat Genet doi: 10.1038/ng.521 – volume: 9 start-page: 415 year: 2008 end-page: 22 ident: CR26 article-title: Polymorphism in human organic cation transporters and metformin action publication-title: Pharmacogenomics doi: 10.2217/14622416.9.4.415 – volume: 494 start-page: 256 year: 2013 end-page: 60 ident: CR13 article-title: Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP publication-title: Nature doi: 10.1038/nature11808 – volume: 53 start-page: 1360 year: 2004 end-page: 8 ident: CR40 article-title: Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region publication-title: Diabetes doi: 10.2337/diabetes.53.5.1360 – volume: 171 start-page: 645 year: 2010 end-page: 55 ident: CR63 article-title: The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis publication-title: Am J Epidemiol doi: 10.1093/aje/kwp450 – volume: 55 start-page: 1971 year: 2012 end-page: 7 ident: CR17 article-title: A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts publication-title: Diabetologia doi: 10.1007/s00125-012-2537-x – volume: 39 start-page: 5511 year: 2012 end-page: 8 ident: CR71 article-title: Polymorphism of adiponectin (45 T/G) and adiponectin receptor-2 (795G/A) in an Iranian population: relation with insulin resistance and response to treatment with pioglitazone in patients with type 2 diabetes mellitus publication-title: Mol Biol Rep doi: 10.1007/s11033-011-1354-5 – volume: 31 start-page: 204 year: 2008 end-page: 9 ident: CR39 article-title: Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations publication-title: Diabetes Care doi: 10.2337/dc07-1785 – volume: 23 start-page: 245 year: 2012 end-page: 9 ident: CR46 article-title: KCNJ11 gene E23K variant and therapeutic response to sulfonylureas publication-title: Eur J Int Med doi: 10.1016/j.ejim.2011.10.018 – volume: 38 start-page: 320 year: 2006 end-page: 3 ident: CR48 article-title: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes publication-title: Nat Genet doi: 10.1038/ng1732 – volume: 355 start-page: 2427 year: 2006 end-page: 43 ident: CR85 article-title: Glycaemic durability of rosiglitazone, metformin, or glyburide monotherapy publication-title: N Engl J Med doi: 10.1056/NEJMoa066224 – volume: 510 start-page: 542 year: 2014 end-page: 6 ident: CR12 article-title: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase publication-title: Nature doi: 10.1038/nature13270 – volume: 26 start-page: 825 year: 2003 end-page: 31 ident: CR68 article-title: Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes publication-title: Diabetes Care doi: 10.2337/diacare.26.3.825 – volume: 59 start-page: 1139 year: 2010 end-page: 44 ident: CR64 article-title: Common polymorphisms of the peroxisome proliferator-activated receptor-γ (Pro12Ala) and peroxisome proliferator-activated receptor-γ coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus publication-title: Metabolism doi: 10.1016/j.metabol.2009.10.030 – volume: 29 start-page: 983 year: 2008 end-page: 9 ident: CR47 article-title: Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients publication-title: Acta Pharmacol Sin doi: 10.1111/j.1745-7254.2008.00840.x – volume: 31 start-page: 1939 year: 2008 end-page: 44 ident: CR44 article-title: Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients publication-title: Diabetes Care doi: 10.2337/dc07-2248 – volume: 24 start-page: 12 year: 2011 end-page: 30 ident: CR56 article-title: TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes publication-title: BMC Med Genet – volume: 83 start-page: 273 year: 2008 end-page: 80 ident: CR25 article-title: Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics publication-title: Clin Pharmacol Ther doi: 10.1038/sj.clpt.6100275 – volume: 10 start-page: 794 year: 2008 end-page: 802 ident: CR70 article-title: The influence of adiponectin gene polymorphism on the pioglitazone response in the Chinese with type 2 diabetes publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2007.00832.x – volume: 57 start-page: 1869 year: 2014 end-page: 75 ident: CR80 article-title: Influence of gene variants on the therapeutic response to the dipeptidylpetidase-4 inhibitor linagliptin publication-title: Diabetologia doi: 10.1007/s00125-014-3276-y – volume: 2013 start-page: 686315 year: 2013 ident: CR2 article-title: Pharmacogenetics of oral antidiabetic drugs publication-title: Int J Endocrionol – volume: 33 start-page: 2074 year: 2010 end-page: 6 ident: CR73 article-title: Common genetic variation in and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects publication-title: Diabetes Care doi: 10.2337/dc10-0200 – volume: 169 start-page: 616 year: 2009 end-page: 25 ident: CR7 article-title: Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes publication-title: Arch Int Med doi: 10.1001/archinternmed.2009.20 – volume: 86 start-page: 299 year: 2009 end-page: 306 ident: CR27 article-title: The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2009.92 – volume: 510 start-page: 542 year: 2014 ident: 617_CR12 publication-title: Nature doi: 10.1038/nature13270 – volume: 368 start-page: 1696 year: 2006 ident: 617_CR72 publication-title: Lancet doi: 10.1016/S0140-6736(06)69705-5 – volume: 55 start-page: 1577 year: 2012 ident: 617_CR1 publication-title: Diabetologia doi: 10.1007/s00125-012-2534-0 – volume: 15 start-page: 189 year: 2013 ident: 617_CR31 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2012.01691.x – volume: 31 start-page: 1939 year: 2008 ident: 617_CR44 publication-title: Diabetes Care doi: 10.2337/dc07-2248 – volume: 298 start-page: 1164 year: 1978 ident: 617_CR20 publication-title: N Engl J Med doi: 10.1056/NEJM197805252982103 – volume: 59 start-page: 1139 year: 2010 ident: 617_CR64 publication-title: Metabolism doi: 10.1016/j.metabol.2009.10.030 – volume: 83 start-page: 273 year: 2008 ident: 617_CR25 publication-title: Clin Pharmacol Ther doi: 10.1038/sj.clpt.6100275 – volume: 9 start-page: 242 year: 2009 ident: 617_CR33 publication-title: Pharmacogenomics J doi: 10.1038/tpj.2009.15 – volume: 34 start-page: 225 year: 2013 ident: 617_CR66 publication-title: Acta Pharmacol Sin – volume: 169 start-page: 616 year: 2009 ident: 617_CR7 publication-title: Arch Int Med doi: 10.1001/archinternmed.2009.20 – volume: 108 start-page: 1167 year: 2001 ident: 617_CR8 publication-title: J Clin Invest doi: 10.1172/JCI13505 – volume: 43 start-page: 117 year: 2011 ident: 617_CR16 publication-title: Nat Genet doi: 10.1038/ng.735 – volume: 33 start-page: 1859 year: 2010 ident: 617_CR5 publication-title: Diabetes Care doi: 10.2337/dc09-1727 – volume: 171 start-page: 645 year: 2010 ident: 617_CR63 publication-title: Am J Epidemiol doi: 10.1093/aje/kwp450 – volume: 91 start-page: 2334 year: 2006 ident: 617_CR43 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2005-2323 – volume: 57 start-page: 1869 year: 2014 ident: 617_CR80 publication-title: Diabetologia doi: 10.1007/s00125-014-3276-y – volume: 523 start-page: 161 year: 2012 ident: 617_CR15 publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2012.04.020 – volume: 10 start-page: 1499 year: 2011 ident: 617_CR21 publication-title: Cell Cycle doi: 10.4161/cc.10.9.15423 – volume: 28 start-page: 1139 year: 2005 ident: 617_CR69 publication-title: Diabetes Care doi: 10.2337/diacare.28.5.1139 – volume: 10 start-page: 33 issue: Suppl 12 year: 2009 ident: 617_CR84 publication-title: Pediatr Diabetes doi: 10.1111/j.1399-5448.2009.00571.x – volume: 77 start-page: 58 year: 2007 ident: 617_CR45 publication-title: Diabetes Res Clin Pract doi: 10.1016/j.diabres.2006.10.021 – volume: 355 start-page: 241 year: 2006 ident: 617_CR53 publication-title: N Engl J Med doi: 10.1056/NEJMoa062418 – volume: 78 start-page: 202 year: 2005 ident: 617_CR65 publication-title: Clin Pharmacol Ther doi: 10.1016/j.clpt.2005.04.013 – volume: 57 start-page: 1715 year: 2009 ident: 617_CR77 publication-title: Diabetes doi: 10.2337/db08-1589 – volume: 38 start-page: 320 year: 2006 ident: 617_CR48 publication-title: Nat Genet doi: 10.1038/ng1732 – volume: 92 start-page: 1502 year: 2007 ident: 617_CR67 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-2275 – volume: 62 start-page: 3275 year: 2013 ident: 617_CR81 publication-title: Diabetes doi: 10.2337/db13-0227 – volume: 57 start-page: 306 year: 2008 ident: 617_CR10 publication-title: Diabetes doi: 10.2337/db07-0381 – volume: 23 start-page: 245 year: 2012 ident: 617_CR46 publication-title: Eur J Int Med doi: 10.1016/j.ejim.2011.10.018 – volume: 2 start-page: 481 year: 2014 ident: 617_CR4 publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70050-6 – volume: 42 start-page: 142 year: 2010 ident: 617_CR74 publication-title: Nat Genet doi: 10.1038/ng.521 – volume: 33 start-page: 2074 year: 2010 ident: 617_CR73 publication-title: Diabetes Care doi: 10.2337/dc10-0200 – volume: 50 start-page: 2443 year: 2007 ident: 617_CR75 publication-title: Diabetologia doi: 10.1007/s00125-007-0753-6 – volume: 362 start-page: 1275 year: 2003 ident: 617_CR83 publication-title: Lancet doi: 10.1016/S0140-6736(03)14571-0 – volume: 21 start-page: 837 year: 2011 ident: 617_CR34 publication-title: Pharmacogenet Genomics doi: 10.1097/FPC.0b013e32834c0010 – volume: 24 start-page: 12 year: 2011 ident: 617_CR56 publication-title: BMC Med Genet – volume: 100 start-page: 4012 year: 2003 ident: 617_CR9 publication-title: Proc Natl Acad Sci doi: 10.1073/pnas.0730870100 – volume: 50 start-page: 81 year: 2011 ident: 617_CR23 publication-title: Clin Pharmacokinet doi: 10.2165/11534750-000000000-00000 – volume: 15 start-page: 91 year: 2013 ident: 617_CR76 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2012.01675.x – volume: 68 start-page: 1462 year: 2014 ident: 617_CR18 publication-title: Int J Clin Pract doi: 10.1111/ijcp.12534 – volume: 9 start-page: 415 year: 2008 ident: 617_CR26 publication-title: Pharmacogenomics doi: 10.2217/14622416.9.4.415 – volume: 61 start-page: 1082 year: 2012 ident: 617_CR79 publication-title: Diabetes doi: 10.2337/db11-1732 – volume: 67 start-page: 797 year: 2011 ident: 617_CR60 publication-title: Eur J Clin Pharmacol doi: 10.1007/s00228-011-1013-8 – volume: 20 start-page: 573 year: 2014 ident: 617_CR61 publication-title: Cell Metab doi: 10.1016/j.cmet.2014.08.005 – volume: 306 start-page: 239 year: 2007 ident: 617_CR22 publication-title: Mol Cell Biochem doi: 10.1007/s11010-007-9575-6 – volume: 10 start-page: 15 year: 2009 ident: 617_CR49 publication-title: BMC Med Genet doi: 10.1186/1471-2350-10-15 – volume: 35 start-page: 1864 year: 2012 ident: 617_CR19 publication-title: Diabetes Care doi: 10.2337/dc11-2301 – volume: 39 start-page: 5511 year: 2012 ident: 617_CR71 publication-title: Mol Biol Rep doi: 10.1007/s11033-011-1354-5 – volume: 58 start-page: 1434 year: 2009 ident: 617_CR35 publication-title: Diabetes doi: 10.2337/db08-0896 – volume: 26 start-page: 825 year: 2003 ident: 617_CR68 publication-title: Diabetes Care doi: 10.2337/diacare.26.3.825 – volume: 52 start-page: 1075 year: 2009 ident: 617_CR78 publication-title: Diabetologia doi: 10.1007/s00125-009-1344-5 – volume: 71 start-page: 286 year: 2002 ident: 617_CR57 publication-title: Clin Pharmacol Ther doi: 10.1067/mcp.2002.122476 – volume: 78 start-page: 90 year: 2005 ident: 617_CR58 publication-title: Clin Pharmacol Ther doi: 10.1016/j.clpt.2005.03.008 – volume: 2013 start-page: 686315 year: 2013 ident: 617_CR2 publication-title: Int J Endocrionol – volume: 352 start-page: 854 year: 1998 ident: 617_CR6 publication-title: Lancet doi: 10.1016/S0140-6736(98)07037-8 – volume: 31 start-page: 204 year: 2008 ident: 617_CR39 publication-title: Diabetes Care doi: 10.2337/dc07-1785 – volume: 2013 start-page: 374858 year: 2013 ident: 617_CR55 publication-title: Int J Endocrinol doi: 10.1155/2013/374858 – volume: 58 start-page: 745 year: 2009 ident: 617_CR30 publication-title: Diabetes doi: 10.2337/db08-1028 – volume: 29 start-page: 983 year: 2008 ident: 617_CR47 publication-title: Acta Pharmacol Sin doi: 10.1111/j.1745-7254.2008.00840.x – volume: 96 start-page: 370 year: 2014 ident: 617_CR36 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2014.109 – volume: 3 start-page: 705 year: 2009 ident: 617_CR3 publication-title: J Diabetes Sci Technol doi: 10.1177/193229680900300415 – volume: 90 start-page: 674 year: 2011 ident: 617_CR32 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2011.165 – volume: 280 start-page: 1457 year: 2005 ident: 617_CR50 publication-title: J Biol Chem doi: 10.1074/jbc.M411487200 – volume: 494 start-page: 256 year: 2013 ident: 617_CR13 publication-title: Nature doi: 10.1038/nature11808 – volume: 117 start-page: 1422 year: 2007 ident: 617_CR24 publication-title: J Clin Invest doi: 10.1172/JCI30558 – volume: 15 start-page: 915 year: 2014 ident: 617_CR82 publication-title: Pharmacogenomics doi: 10.2217/pgs.14.17 – volume: 59 start-page: 479 year: 2010 ident: 617_CR52 publication-title: Diabetes doi: 10.2337/db09-1169 – volume: 18 start-page: 206 year: 2001 ident: 617_CR42 publication-title: Diabet Med doi: 10.1046/j.1464-5491.2001.00449.x – volume: 110 start-page: 655 year: 1997 ident: 617_CR37 publication-title: J Genet Physiol doi: 10.1085/jgp.110.6.655 – volume: 53 start-page: 1360 year: 2004 ident: 617_CR40 publication-title: Diabetes doi: 10.2337/diabetes.53.5.1360 – volume: 355 start-page: 467 year: 2006 ident: 617_CR38 publication-title: N Engl J Med doi: 10.1056/NEJMoa061759 – volume: 58 start-page: 2419 year: 2009 ident: 617_CR41 publication-title: Diabetes doi: 10.2337/db09-0143 – volume: 355 start-page: 2427 year: 2006 ident: 617_CR85 publication-title: N Engl J Med doi: 10.1056/NEJMoa066224 – volume: 120 start-page: 2355 year: 2010 ident: 617_CR11 publication-title: J Clin Invest doi: 10.1172/JCI40671 – volume: 93 start-page: 186 year: 2013 ident: 617_CR29 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2012.210 – volume: 241 start-page: 270 year: 1997 ident: 617_CR62 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1997.7798 – volume: 55 start-page: 1971 year: 2012 ident: 617_CR17 publication-title: Diabetologia doi: 10.1007/s00125-012-2537-x – volume: 56 start-page: 2178 year: 2007 ident: 617_CR54 publication-title: Diabetes doi: 10.2337/db07-0440 – volume: 55 start-page: 2890 year: 2006 ident: 617_CR51 publication-title: Diabetes doi: 10.2337/db06-0381 – volume: 87 start-page: 52 year: 2010 ident: 617_CR59 publication-title: Clin Pharmacol Therap. doi: 10.1038/clpt.2009.176 – volume: 86 start-page: 299 year: 2009 ident: 617_CR27 publication-title: Clin Pharmacol Ther doi: 10.1038/clpt.2009.92 – volume: 59 start-page: 2672 year: 2010 ident: 617_CR14 publication-title: Diabetes doi: 10.2337/db10-0543 – volume: 52 start-page: 117 year: 2007 ident: 617_CR28 publication-title: J Hum Genet doi: 10.1007/s10038-006-0087-0 – volume: 10 start-page: 794 year: 2008 ident: 617_CR70 publication-title: Diabetes Obes Metab doi: 10.1111/j.1463-1326.2008.00905.x |
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| SubjectTerms | Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Genetics (AP Morris Humans Hypoglycemic Agents - therapeutic use Insulin - metabolism Insulin Secretion Medicine Medicine & Public Health Pharmacogenetics Section Editor Topical Collection on Genetics Treatment Outcome |
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| Title | Genetics of Drug Response in Type 2 Diabetes |
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