Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects

• Published in: Journal of Nuclear Medicine Vol. 58; no. 5; pp. 807 - 814
• Main Authors: Joseph, James, Tomaszewski, Michal R., Quiros-Gonzalez, Isabel, Weber, Judith, Brunker, Joanna, Bohndiek, Sarah E.
• Format: Journal Article
• Language: English
• Published: United States Society of Nuclear Medicine 01.05.2017
• Subjects: Accuracy; Anesthesia; Animals; Coefficient of variation; Data acquisition; Elasticity Imaging Techniques - instrumentation; Elasticity Imaging Techniques - veterinary; Equipment Design; Equipment Failure Analysis; In vivo methods and tests; Kidney - anatomy & histology; Kidneys; Mice; Mice, Inbred BALB C; Mice, Nude; Nuclear medicine; Organs; Phantoms, Imaging; Photoacoustic Techniques - instrumentation; Photoacoustic Techniques - veterinary; Placement; Precision; Reproducibility; Reproducibility of Results; Sensitivity and Specificity; Spleen; Spleen - anatomy & histology; Temporal variations; Tomography; Tomography, Optical - instrumentation; Tomography, Optical - veterinary; Variation; phantoms; repeatability; in vivo imaging; optoacoustic imaging; reproducibility

Optoacoustic tomography (OT) is now widely used in preclinical imaging; however, the precision (repeatability and reproducibility) of OT has yet to be determined. We used a commercial small-animal OT system. Measurements in stable phantoms were used to independently assess the impact of system varia...