Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27

• Published in: Journal of physiology and biochemistry Vol. 79; no. 1; pp. 163 - 174
• Main Authors: Wang, Yi-Xuan, Huang, Chun-Yang, Chiu, Hsiao-Ju, Huang, Po-Han, Chien, Hung-Ting, Jwo, Si-Han, Liao, Yi-Chun
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2023; Springer; Springer Nature B.V
• Subjects: Accumulation; Animal Physiology; Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome; Biomedical and Life Sciences; Biomedicine; Cancer; Cell adhesion; Cell adhesion & migration; Cell Adhesion - physiology; Cell division; Cell migration; Cell Movement; Chromatin; Colorectal cancer; Colorectal carcinoma; Cycle protein; Deoxyribonucleic acid; DNA; Ethylenediaminetetraacetic acid; Gene expression; Genes; Genetic aspects; Genetic transcription; Human Physiology; Humans; Localization; Metastasis; Microfilament Proteins - genetics; Neoplasms; Original Article; Proteins; RNA; RNA, Messenger - genetics; Tensin; Tensins - genetics; Tensins - metabolism; Transcription; Transcription initiation; Nuclear-localized; Transcriptional regulator; CTEN; Cell migration; CDC27

C-terminal tensin-like (CTEN) is a tensin family protein typically localized to the cytoplasmic side of focal adhesions, and primarily contributes to cell adhesion and migration. Elevated expression and nuclear accumulation of CTEN have been reported in several types of cancers and found to be assoc...