Antioxidant resveratrol protects against copper oxide nanoparticle toxicity in vivo

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 391; no. 10; pp. 1053 - 1062
• Main Authors: Khalid, Sana, Afzal, Nabeel, Khan, Junaid Ali, Hussain, Zulfia, Qureshi, Anas Sarwar, Anwar, Hafeez, Jamil, Yasir
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2018; Springer Nature B.V
• Subjects: Animals; Antioxidants; Antioxidants - pharmacology; Biomedical and Life Sciences; Biomedicine; Copper; Copper - toxicity; Copper oxides; Creatinine; Creatinine - blood; Hepatotoxicity; Kidney - drug effects; Kidney - pathology; Lattice parameters; Male; Nanoparticles; Nanoparticles - toxicity; Neurosciences; Original Article; Oxidative stress; Oxidative Stress - drug effects; Pharmacology/Toxicology; Rats, Wistar; Resveratrol; Resveratrol - pharmacology; Rodents; Scanning electron microscopy; Serum levels; Stilbene; Urea; Urea - blood; X-ray diffraction; Oxidative stress; Histopathology; Hepatotoxicity; Nephrotoxicity; Resveratrol; Copper oxide nanoparticles

The upsurge in copper oxide nanoparticle (CuONP) applications in various fields triggers hazardous effects on health. Resveratrol, a polyphenol found in plants of stilbene class, has been reported to decrease oxidative stress. The current study investigated the protective effect of resveratrol (RVT)...