On the Increase in Network Robustness and Decrease in Network Response Ability during the Aging Process: A Systems Biology Approach via Microarray Data

• Published in: IEEE/ACM transactions on computational biology and bioinformatics Vol. 10; no. 2; pp. 468 - 480
• Main Authors: Tu, Chien-Ta, Chen, Bor-Sen
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.03.2013; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Aging; Aging - genetics; Caloric Restriction; Diseases; Forkhead Transcription Factors; Gene regulatory network; Gene Regulatory Networks; Genes; Genes, p53; Humans; Mice; network analysis; network response ability; network robustness; NF-kappa B - genetics; Older people; Oligonucleotide Array Sequence Analysis; Organ Specificity; Proteins - analysis; Proteins - genetics; Proteins - metabolism; Robustness; Stress; Systematics; systems biology; Systems Biology - methods

Aging, an extremely complex and system-level process, has attracted much attention in medical research, especially since chronic diseases are quite prevalent in the elderly population. These may be the result of both gene mutations that lead to intrinsic perturbations and environmental changes that...